prikaz prve stranice dokumenta The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial
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The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial
European Journal of Clinical Nutrition, 76 (2022), 12; 1675-1681. https://doi.org/10.1038/s41430-022-01189-0
Fehir Šola, Katarina; Vladimir-Knežević, Sanda; Hrabač, Pero; Mucalo, Iva; Saso, Luciano; Verbanac, Donatella

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Fehir Šola, K., Vladimir Knežević, S., Hrabač, P., Mucalo, I., Saso, L. i Verbanac, D. (2022). The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. European Journal of Clinical Nutrition, 76. (12), 1675-1681. doi: 10.1038/s41430-022-01189-0

Fehir Šola, Katarina, et al. "The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial." European Journal of Clinical Nutrition, vol. 76, br. 12, 2022, str. 1675-1681. https://doi.org/10.1038/s41430-022-01189-0

Fehir Šola, Katarina, Sanda Vladimir Knežević, Pero Hrabač, Iva Mucalo, Luciano Saso i Donatella Verbanac. "The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial." European Journal of Clinical Nutrition 76, br. 12 (2022): 1675-1681. https://doi.org/10.1038/s41430-022-01189-0

Fehir Šola, K., et al. (2022) 'The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial', European Journal of Clinical Nutrition, 76(12), str. 1675-1681. doi: 10.1038/s41430-022-01189-0

Fehir Šola K, Vladimir Knežević S, Hrabač P, Mucalo I, Saso L, Verbanac D. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. European Journal of Clinical Nutrition [Internet]. 04.08.2022. [pristupljeno 22.11.2024.];76(12):1675-1681. doi: 10.1038/s41430-022-01189-0

K. Fehir Šola, S. Vladimir Knežević, P. Hrabač, I. Mucalo, L. Saso i D. Verbanac, "The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial", European Journal of Clinical Nutrition, vol. 76, br. 12, str. 1675-1681, Kolovoz 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:628271. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:628271
Podaci o radu
Naslov (engleski)The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial
AutorKatarina Fehir Šola
AutorSanda Vladimir-Knežević
AutorPero Hrabač
AutorIva Mucalo
AutorLuciano Saso
AutorDonatella Verbanac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU STATISTIKU, EPIDEMIOLOGIJU I MEDICINSKU INFORMATIKU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Epidemiologija
Sažetak (engleski)
Background and objectives: Constipation is one of the most common gastrointestinal conditions, particularly among older individuals. This study aimed to evaluate the efficacy and safety of selected multistrain probiotics on functional constipation and laboratory blood parameters in the elderly living in a nursing home. ----- Subjects and methods: Sixty participants (42 females and 18 males) aged 77.9 ± 8.84 years with functional constipation, who met the eligibility criteria, completed the study. In a double-blind, placebo-controlled, parallel design, each participant was randomized to receive either the selected probiotic mixture (N = 28) or placebo (N = 32) for 12 weeks as an adjunct to their usual diet and medications. The liquid probiotic formulation containing Bifidobacterium animalis subsp. lactis BLC1, Lactobacillus acidophilus LA3 and Lactobacillus casei BGP93 was tested for the first time. ----- Results: Supplementation of selected probiotics resulted in a slight but nonsignificant increase in cumulative stool frequency compared with placebo. However, after the 71st day of the treatment, the cumulative number of stools was significantly higher in the probiotic group (P < 0.05) when the influence of laxative was excluded. The trend towards an increase in the difference between the two groups, which began 1 week after the probiotic intervention, pointed out to their prolonged effect. There were no significant dependent or independent effects of treatment and time on most of the 27 laboratory blood parameters tested. ----- Conclusions: Multistrain probiotic supplementation was found to be efficacious, safe and well tolerated in the elderly with functional constipation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Clinical Nutrition
Brojčani podacivol. 76, br. 12, str. 1675-1681
p-ISSN0954-3007
e-ISSN1476-5640
DOIhttps://doi.org/10.1038/s41430-022-01189-0
URN:NBNurn:nbn:hr:105:628271
Datum objave publikacije2022-08-04
URL dokumentahttps://www.nature.com/articles/s41430-022-01189-0
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-03-14 09:50:34