prikaz prve stranice dokumenta Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?
  Download
PDF 854.97 KB
Scientific paper - Original scientific paper
Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?
Biomedicines, 10 (2022), 7; 1518. https://doi.org/10.3390/biomedicines10071518
Puljko, Borna; Stojanović, Mario; Ilić, Katarina; Kalanj-Bognar, Svjetlana; Mlinac-Jerković, Kristina

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Puljko, B., Stojanović, M., Ilić, K., Kalanj Bognar, S. & Mlinac Jerković, K. (2022). Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?. Biomedicines, 10. (7). doi: 10.3390/biomedicines10071518

Puljko, Borna, et al. "Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?." Biomedicines, vol. 10, no. 7, 2022. https://doi.org/10.3390/biomedicines10071518

Puljko, Borna, Mario Stojanović, Katarina Ilić, Svjetlana Kalanj Bognar and Kristina Mlinac Jerković. "Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?." Biomedicines 10, no. 7 (2022). https://doi.org/10.3390/biomedicines10071518

Puljko, B., et al. (2022) 'Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?', Biomedicines, 10(7). doi: 10.3390/biomedicines10071518

Puljko B, Stojanović M, Ilić K, Kalanj Bognar S, Mlinac Jerković K. Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?. Biomedicines [Internet]. 2022 June 27 [cited 2024 November 26];10(7). doi: 10.3390/biomedicines10071518

B. Puljko, M. Stojanović, K. Ilić, S. Kalanj Bognar and K. Mlinac Jerković, "Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?", Biomedicines, vol. 10, no. 7, June 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:685787. [Accessed: 26 November 2024]

Metadata
Title (english)Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?
AuthorBorna Puljko
AuthorMario Stojanović
AuthorKatarina Ilić
AuthorSvjetlana Kalanj-Bognar
AuthorKristina Mlinac-Jerković
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Chemistry, Biochemistry and Clinical Chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
Gangliosides, amphiphilic glycosphingolipids, tend to associate laterally with other membrane constituents and undergo extensive interactions with membrane proteins in cis or trans configurations. Studies of human diseases resulting from mutations in the ganglioside biosynthesis pathway and research on transgenic mice with the same mutations implicate gangliosides in the pathogenesis of epilepsy. Gangliosides are reported to affect the activity of the Na+/K+-ATPase, the ubiquitously expressed plasma membrane pump responsible for the stabilization of the resting membrane potential by hyperpolarization, firing up the action potential and ion homeostasis. Impaired Na+/K+-ATPase activity has also been hypothesized to cause seizures by several mechanisms. In this review we present different epileptic phenotypes that are caused by impaired activity of Na+/K+-ATPase or changed membrane ganglioside composition. We further discuss how gangliosides may influence Na+/K+-ATPase activity by acting as lipid sorting machinery providing the optimal stage for Na+/K+-ATPase function. By establishing a distinct lipid environment, together with other membrane lipids, gangliosides possibly modulate Na+/K+-ATPase activity and aid in “starting up” and “turning off” this vital pump. Therefore, structural changes of neuronal membranes caused by altered ganglioside composition can be a contributing factor leading to aberrant Na+/K+-ATPase activity and ion imbalance priming neurons for pathological firing.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 10, no. 7, 1518
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10071518
URN:NBNurn:nbn:hr:105:685787
Publication2022-06-27
ProjectNumber: IP-2016-06-8636
Title (croatian): Molekularni biljezi vulnerabilnosti, adaptacije i plastičnosti neurona u akutnoj i kroničnoj ozljedi mozga
Acronym: NeuroReact
Leader: Svjetlana Kalanj-Bognar
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: KK.01.1.1.01.0007
Title (english): Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Leader: Ivica Kostović
Jurisdiction: Croatia
Document URLhttps://www.mdpi.com/2227-9059/10/7/1518
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-03-20 11:35:09