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Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?
Biomedicines, 10 (2022), 7; 1518. https://doi.org/10.3390/biomedicines10071518
Puljko, Borna; Stojanović, Mario; Ilić, Katarina; Kalanj-Bognar, Svjetlana; Mlinac-Jerković, Kristina

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Puljko, B., Stojanović, M., Ilić, K., Kalanj Bognar, S. i Mlinac Jerković, K. (2022). Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?. Biomedicines, 10. (7). doi: 10.3390/biomedicines10071518

Puljko, Borna, et al. "Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?." Biomedicines, vol. 10, br. 7, 2022. https://doi.org/10.3390/biomedicines10071518

Puljko, Borna, Mario Stojanović, Katarina Ilić, Svjetlana Kalanj Bognar i Kristina Mlinac Jerković. "Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?." Biomedicines 10, br. 7 (2022). https://doi.org/10.3390/biomedicines10071518

Puljko, B., et al. (2022) 'Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?', Biomedicines, 10(7). doi: 10.3390/biomedicines10071518

Puljko B, Stojanović M, Ilić K, Kalanj Bognar S, Mlinac Jerković K. Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?. Biomedicines [Internet]. 27.06.2022. [pristupljeno 23.12.2024.];10(7). doi: 10.3390/biomedicines10071518

B. Puljko, M. Stojanović, K. Ilić, S. Kalanj Bognar i K. Mlinac Jerković, "Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?", Biomedicines, vol. 10, br. 7, Lipanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:685787. [Citirano: 23.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:685787
Podaci o radu
Naslov (engleski)Start Me Up: How Can Surrounding Gangliosides Affect Sodium-Potassium ATPase Activity and Steer towards Pathological Ion Imbalance in Neurons?
AutorBorna Puljko
AutorMario Stojanović
AutorKatarina Ilić
AutorSvjetlana Kalanj-Bognar
AutorKristina Mlinac-Jerković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU KEMIJU, BIOKEMIJU I KLINIČKU KEMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Gangliosides, amphiphilic glycosphingolipids, tend to associate laterally with other membrane constituents and undergo extensive interactions with membrane proteins in cis or trans configurations. Studies of human diseases resulting from mutations in the ganglioside biosynthesis pathway and research on transgenic mice with the same mutations implicate gangliosides in the pathogenesis of epilepsy. Gangliosides are reported to affect the activity of the Na+/K+-ATPase, the ubiquitously expressed plasma membrane pump responsible for the stabilization of the resting membrane potential by hyperpolarization, firing up the action potential and ion homeostasis. Impaired Na+/K+-ATPase activity has also been hypothesized to cause seizures by several mechanisms. In this review we present different epileptic phenotypes that are caused by impaired activity of Na+/K+-ATPase or changed membrane ganglioside composition. We further discuss how gangliosides may influence Na+/K+-ATPase activity by acting as lipid sorting machinery providing the optimal stage for Na+/K+-ATPase function. By establishing a distinct lipid environment, together with other membrane lipids, gangliosides possibly modulate Na+/K+-ATPase activity and aid in “starting up” and “turning off” this vital pump. Therefore, structural changes of neuronal membranes caused by altered ganglioside composition can be a contributing factor leading to aberrant Na+/K+-ATPase activity and ion imbalance priming neurons for pathological firing.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 10, br. 7, 1518
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10071518
URN:NBNurn:nbn:hr:105:685787
Datum objave publikacije2022-06-27
ProjektŠifra: IP-2016-06-8636
Naziv (hrvatski): Molekularni biljezi vulnerabilnosti, adaptacije i plastičnosti neurona u akutnoj i kroničnoj ozljedi mozga
Kratica: NeuroReact
Voditelj: Svjetlana Kalanj-Bognar
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: KK.01.1.1.01.0007
Naziv (engleski): Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Voditelj: Ivica Kostović
Pravna nadležnost: Hrvatska
Financijer: EK
URL dokumentahttps://www.mdpi.com/2227-9059/10/7/1518
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-03-20 11:35:09