prikaz prve stranice dokumenta Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia
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Scientific paper - Original scientific paper
Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia
Microorganisms, 10 (2022), 7; 1443. https://doi.org/10.3390/microorganisms10071443
Vilibić-Čavlek, Tatjana; Stevanović, Vladimir; Savić, Vladimir; Markelić, Domagoj; Sabadi, Dario; Bogdanić, Maja; Kovač, Snježana; Santini, Marija; Tabain, Irena; Potočnik-Hunjadi, Tanja; Ferenčak, Ivana; Škoda, Ana Marija; Sanković, Ana; Barbić, Ljubo

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Vilibić Čavlek, T., Stevanović, V., Savić, V., Markelić, D., Sabadi, D., Bogdanić, M. ... Barbić, Lj. (2022). Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia. Microorganisms, 10. (7). doi: 10.3390/microorganisms10071443

Vilibić Čavlek, Tatjana, et al. "Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia." Microorganisms, vol. 10, no. 7, 2022. https://doi.org/10.3390/microorganisms10071443

Vilibić Čavlek, Tatjana, Vladimir Stevanović, Vladimir Savić, Domagoj Markelić, Dario Sabadi, Maja Bogdanić, Snježana Kovač, et al. "Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia." Microorganisms 10, no. 7 (2022). https://doi.org/10.3390/microorganisms10071443

Vilibić Čavlek, T., et al. (2022) 'Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia', Microorganisms, 10(7). doi: 10.3390/microorganisms10071443

Vilibić Čavlek T, Stevanović V, Savić V, Markelić D, Sabadi D, Bogdanić M, and sur.. Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia. Microorganisms [Internet]. 2022 July 18 [cited 2024 November 26];10(7). doi: 10.3390/microorganisms10071443

T. Vilibić Čavlek, et al., "Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia", Microorganisms, vol. 10, no. 7, July 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:442132. [Accessed: 26 November 2024]

Metadata
Title (english)Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia
AuthorTatjana Vilibić-Čavlek
AuthorVladimir Stevanović
AuthorVladimir Savić
AuthorDomagoj Markelić
AuthorDario Sabadi
AuthorMaja Bogdanić
AuthorSnježana Kovač
AuthorMarija Santini
AuthorIrena Tabain
AuthorTanja Potočnik-Hunjadi
AuthorIvana Ferenčak
AuthorAna Marija Škoda
AuthorAna Sanković
AuthorLjubo Barbić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Background: Tahyna orthobunyavirus (TAHV) is widely distributed in continental Europe. Very few studies have analyzed TAHV seroprevalence in Croatia. We analyzed the prevalence of TAHV RNA and antibodies in Croatian patients with neuroinvasive disease (NID). Methods: A total of 218 patients with unsolved NID detected during five consecutive arbovirus transmission seasons (April 2017-October 2021) were tested. Cerebrospinal fluid (CSF) and urine samples were tested for TAHV RNA using RT-PCR. In addition, CSF and serum samples were tested for TAHV antibodies using a virus neutralization test (VNT). Results: Clinical presentations in patients with NID were meningitis (141/64.7%), meningoencephalitis (56/25.7%), myelitis (8/3.7%), and 'febrile headache' (13/5.9%). TAHV RNA was not detected in any of the tested CSF or urine samples; however, TAHV-neutralizing (NT) antibodies were detected in 22/10.1% of patients. Detection of NT antibodies in the CSF of two patients presenting with meningitis suggested recent TAHV infection. TAHV seropositivity increased significantly with age, from 1.8% to 24.4%. There was no difference in seroprevalence between genders or areas of residence (urban, suburban/rural). The majority of seropositive patients (90.9%) resided in floodplains along the rivers in continental Croatia. Conclusions: The presented results confirm that TAHV is present in Croatia. The prevalence and clinical significance of TAHV infection in the Croatian population have yet to be determined.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMicroorganisms
Numberingvol. 10, no. 7, 1443
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms10071443
URN:NBNurn:nbn:hr:105:442132
Publication2022-07-18
ProjectNumber: IP-2016-06-7456
Title (croatian): Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske
Acronym: CRONEUROARBO
Leader: Tatjana Vilibić Čavlek
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.mdpi.com/2076-2607/10/7/1443
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-03-23 12:48:24