prikaz prve stranice dokumenta Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia
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Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia
Microorganisms, 10 (2022), 7; 1443. https://doi.org/10.3390/microorganisms10071443
Vilibić-Čavlek, Tatjana; Stevanović, Vladimir; Savić, Vladimir; Markelić, Domagoj; Sabadi, Dario; Bogdanić, Maja; Kovač, Snježana; Santini, Marija; Tabain, Irena; Potočnik-Hunjadi, Tanja; Ferenčak, Ivana; Škoda, Ana Marija; Sanković, Ana; Barbić, Ljubo

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Vilibić Čavlek, T., Stevanović, V., Savić, V., Markelić, D., Sabadi, D., Bogdanić, M. ... Barbić, Lj. (2022). Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia. Microorganisms, 10. (7). doi: 10.3390/microorganisms10071443

Vilibić Čavlek, Tatjana, et al. "Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia." Microorganisms, vol. 10, br. 7, 2022. https://doi.org/10.3390/microorganisms10071443

Vilibić Čavlek, Tatjana, Vladimir Stevanović, Vladimir Savić, Domagoj Markelić, Dario Sabadi, Maja Bogdanić, Snježana Kovač, et al. "Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia." Microorganisms 10, br. 7 (2022). https://doi.org/10.3390/microorganisms10071443

Vilibić Čavlek, T., et al. (2022) 'Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia', Microorganisms, 10(7). doi: 10.3390/microorganisms10071443

Vilibić Čavlek T, Stevanović V, Savić V, Markelić D, Sabadi D, Bogdanić M, i sur.. Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia. Microorganisms [Internet]. 18.07.2022. [pristupljeno 09.11.2024.];10(7). doi: 10.3390/microorganisms10071443

T. Vilibić Čavlek, et al., "Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia", Microorganisms, vol. 10, br. 7, Srpanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:442132. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:442132
Podaci o radu
Naslov (engleski)Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia
AutorTatjana Vilibić-Čavlek
AutorVladimir Stevanović
AutorVladimir Savić
AutorDomagoj Markelić
AutorDario Sabadi
AutorMaja Bogdanić
AutorSnježana Kovač
AutorMarija Santini
AutorIrena Tabain
AutorTanja Potočnik-Hunjadi
AutorIvana Ferenčak
AutorAna Marija Škoda
AutorAna Sanković
AutorLjubo Barbić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Background: Tahyna orthobunyavirus (TAHV) is widely distributed in continental Europe. Very few studies have analyzed TAHV seroprevalence in Croatia. We analyzed the prevalence of TAHV RNA and antibodies in Croatian patients with neuroinvasive disease (NID). Methods: A total of 218 patients with unsolved NID detected during five consecutive arbovirus transmission seasons (April 2017-October 2021) were tested. Cerebrospinal fluid (CSF) and urine samples were tested for TAHV RNA using RT-PCR. In addition, CSF and serum samples were tested for TAHV antibodies using a virus neutralization test (VNT). Results: Clinical presentations in patients with NID were meningitis (141/64.7%), meningoencephalitis (56/25.7%), myelitis (8/3.7%), and 'febrile headache' (13/5.9%). TAHV RNA was not detected in any of the tested CSF or urine samples; however, TAHV-neutralizing (NT) antibodies were detected in 22/10.1% of patients. Detection of NT antibodies in the CSF of two patients presenting with meningitis suggested recent TAHV infection. TAHV seropositivity increased significantly with age, from 1.8% to 24.4%. There was no difference in seroprevalence between genders or areas of residence (urban, suburban/rural). The majority of seropositive patients (90.9%) resided in floodplains along the rivers in continental Croatia. Conclusions: The presented results confirm that TAHV is present in Croatia. The prevalence and clinical significance of TAHV infection in the Croatian population have yet to be determined.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMicroorganisms
Brojčani podacivol. 10, br. 7, 1443
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms10071443
URN:NBNurn:nbn:hr:105:442132
Datum objave publikacije2022-07-18
ProjektŠifra: IP-2016-06-7456
Naziv (hrvatski): Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske
Kratica: CRONEUROARBO
Voditelj: Tatjana Vilibić Čavlek
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/2076-2607/10/7/1443
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-03-23 12:48:24