prikaz prve stranice dokumenta Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance
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Scientific paper - Original scientific paper
Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance
Current Microbiology, 79 (2022), 12; 355. https://doi.org/10.1007/s00284-022-03026-w
Bedenić, Branka; Pešorda, Lucija; Krilanović, Marija; Beader, Nataša; Veir, Zoran; Schoenthaler, Silvia; Bandić-Pavlović, Daniela; Frančula-Zaninović, Sonja; Barišić, Ivan

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Bedenić, B., Pešorda, L., Krilanović, M., Beader, N., Veir, Z., Schoenthaler, S. ... Barišić, I. (2022). Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance. Current Microbiology, 79. (12). doi: 10.1007/s00284-022-03026-w

Bedenić, Branka, et al. "Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance." Current Microbiology, vol. 79, no. 12, 2022. https://doi.org/10.1007/s00284-022-03026-w

Bedenić, Branka, Lucija Pešorda, Marija Krilanović, Nataša Beader, Zoran Veir, Silvia Schoenthaler, Daniela Bandić Pavlović, Sonja Frančula Zaninović and Ivan Barišić. "Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance." Current Microbiology 79, no. 12 (2022). https://doi.org/10.1007/s00284-022-03026-w

Bedenić, B., et al. (2022) 'Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance', Current Microbiology, 79(12). doi: 10.1007/s00284-022-03026-w

Bedenić B, Pešorda L, Krilanović M, Beader N, Veir Z, Schoenthaler S, and sur.. Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance. Current Microbiology [Internet]. 2022 October 15 [cited 2024 April 27];79(12). doi: 10.1007/s00284-022-03026-w

B. Bedenić, et al., "Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance", Current Microbiology, vol. 79, no. 12, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:972031. [Accessed: 27 April 2024]

Metadata
Title (english)Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance
AuthorBranka Bedenić
AuthorLucija Pešorda
AuthorMarija Krilanović
AuthorNataša Beader
AuthorZoran Veir
AuthorSilvia Schoenthaler
AuthorDaniela Bandić-Pavlović
AuthorSonja Frančula-Zaninović
AuthorIvan Barišić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
K. pneumoniae isolates often harbor various antibiotic resistance determinants including extended-spectrum β-lactamases (ESBLs), plasmid-mediated AmpC β-lactamases (p-Amp-C) and carbapenemases. In this study we analyzed 65 K. pneumoniae isolates obtained from urinary tract infections in the outpatients setting, with regard to antibiotic susceptibility, β-lactamase production, virulence traits and plasmid content.Antibiotic susceptibility was determined by broth microdilution method. PCR was applied to detect genes encoding ESBLs, p-Amp-C and carbapenemases and plasmid incompatibility groups. Phenotypic methods were applied to characterize virulence determinants. Increasing resistance trend was observed for amoxicillin/clavulanate, imipenem, meropenem and ciprofloxacin. The study showed that ESBLs belonging to the CTX-M family, conferring high level of resistance to expanded-spectrum cephalosporins (ESC) were the dominant resistance trait among early isolates (2013 to 2016) whereas OXA-48 carbapenemase, belonging to class D, emerged in significant numbers after 2017. OXA-48 producing organisms coharbored ESBLs. KPC-2 was dominant among isolates from Dubrovnik in the recent years. Colistin resistance was reported in three isolates. Inc L/M was the dominant plasmid in the later period, encoding OXA-48. Hyperviscosity was linked to KPC positivity and emerged in the later period. This report describes evolution of antibiotic resistance in K. pneumoniae from ESBLs to carbapenemases and colistin resistance. The study demonstrated the ability of K. pneumoniae to acquire various resistance determinants, over time. The striking diversity of the UTI isolates could result from introduction of the isolates from the hospitals, transfer of plasmids and multidirectional evolution.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleCurrent Microbiology
Numberingvol. 79, no. 12, 355
p-ISSN0343-8651
e-ISSN1432-0991
DOIhttps://doi.org/10.1007/s00284-022-03026-w
URN:NBNurn:nbn:hr:105:972031
Publication2022-10-15
Document URLhttps://link.springer.com/10.1007/s00284-022-03026-w
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2023-11-01
Terms of useLicence In copyright icon
Created on2023-04-14 10:48:13