prikaz prve stranice dokumenta Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance
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Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance
Current Microbiology, 79 (2022), 12; 355. https://doi.org/10.1007/s00284-022-03026-w
Bedenić, Branka; Pešorda, Lucija; Krilanović, Marija; Beader, Nataša; Veir, Zoran; Schoenthaler, Silvia; Bandić-Pavlović, Daniela; Frančula-Zaninović, Sonja; Barišić, Ivan

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Bedenić, B., Pešorda, L., Krilanović, M., Beader, N., Veir, Z., Schoenthaler, S. ... Barišić, I. (2022). Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance. Current Microbiology, 79. (12). doi: 10.1007/s00284-022-03026-w

Bedenić, Branka, et al. "Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance." Current Microbiology, vol. 79, br. 12, 2022. https://doi.org/10.1007/s00284-022-03026-w

Bedenić, Branka, Lucija Pešorda, Marija Krilanović, Nataša Beader, Zoran Veir, Silvia Schoenthaler, Daniela Bandić Pavlović, Sonja Frančula Zaninović i Ivan Barišić. "Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance." Current Microbiology 79, br. 12 (2022). https://doi.org/10.1007/s00284-022-03026-w

Bedenić, B., et al. (2022) 'Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance', Current Microbiology, 79(12). doi: 10.1007/s00284-022-03026-w

Bedenić B, Pešorda L, Krilanović M, Beader N, Veir Z, Schoenthaler S, i sur.. Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance. Current Microbiology [Internet]. 15.10.2022. [pristupljeno 26.11.2024.];79(12). doi: 10.1007/s00284-022-03026-w

B. Bedenić, et al., "Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance", Current Microbiology, vol. 79, br. 12, Listopad 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:972031. [Citirano: 26.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:972031
Podaci o radu
Naslov (engleski)Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance
AutorBranka Bedenić
AutorLucija Pešorda
AutorMarija Krilanović
AutorNataša Beader
AutorZoran Veir
AutorSilvia Schoenthaler
AutorDaniela Bandić-Pavlović
AutorSonja Frančula-Zaninović
AutorIvan Barišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
K. pneumoniae isolates often harbor various antibiotic resistance determinants including extended-spectrum β-lactamases (ESBLs), plasmid-mediated AmpC β-lactamases (p-Amp-C) and carbapenemases. In this study we analyzed 65 K. pneumoniae isolates obtained from urinary tract infections in the outpatients setting, with regard to antibiotic susceptibility, β-lactamase production, virulence traits and plasmid content.Antibiotic susceptibility was determined by broth microdilution method. PCR was applied to detect genes encoding ESBLs, p-Amp-C and carbapenemases and plasmid incompatibility groups. Phenotypic methods were applied to characterize virulence determinants. Increasing resistance trend was observed for amoxicillin/clavulanate, imipenem, meropenem and ciprofloxacin. The study showed that ESBLs belonging to the CTX-M family, conferring high level of resistance to expanded-spectrum cephalosporins (ESC) were the dominant resistance trait among early isolates (2013 to 2016) whereas OXA-48 carbapenemase, belonging to class D, emerged in significant numbers after 2017. OXA-48 producing organisms coharbored ESBLs. KPC-2 was dominant among isolates from Dubrovnik in the recent years. Colistin resistance was reported in three isolates. Inc L/M was the dominant plasmid in the later period, encoding OXA-48. Hyperviscosity was linked to KPC positivity and emerged in the later period. This report describes evolution of antibiotic resistance in K. pneumoniae from ESBLs to carbapenemases and colistin resistance. The study demonstrated the ability of K. pneumoniae to acquire various resistance determinants, over time. The striking diversity of the UTI isolates could result from introduction of the isolates from the hospitals, transfer of plasmids and multidirectional evolution.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaCurrent Microbiology
Brojčani podacivol. 79, br. 12, 355
p-ISSN0343-8651
e-ISSN1432-0991
DOIhttps://doi.org/10.1007/s00284-022-03026-w
URN:NBNurn:nbn:hr:105:972031
Datum objave publikacije2022-10-15
URL dokumentahttps://link.springer.com/10.1007/s00284-022-03026-w
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2023-11-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-04-14 10:48:13