prikaz prve stranice dokumenta LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
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Scientific paper - Review paper
LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
International Journal of Molecular Sciences, 23 (2022), 13; 7245. https://doi.org/10.3390/ijms23137245
Krsnik, Dajana; Marić, Tihana; Bulić-Jakuš, Floriana; Sinčić, Nino; Katušić Bojanac, Ana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Krsnik, D., Marić, T., Bulić Jakuš, F., Sinčić, N. & Katušić Bojanac, A. (2022). LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging. International Journal of Molecular Sciences, 23. (13). doi: 10.3390/ijms23137245

Krsnik, Dajana, et al. "LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging." International Journal of Molecular Sciences, vol. 23, no. 13, 2022. https://doi.org/10.3390/ijms23137245

Krsnik, Dajana, Tihana Marić, Floriana Bulić Jakuš, Nino Sinčić and Ana Katušić Bojanac. "LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging." International Journal of Molecular Sciences 23, no. 13 (2022). https://doi.org/10.3390/ijms23137245

Krsnik, D., et al. (2022) 'LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging', International Journal of Molecular Sciences, 23(13). doi: 10.3390/ijms23137245

Krsnik D, Marić T, Bulić Jakuš F, Sinčić N, Katušić Bojanac A. LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging. International Journal of Molecular Sciences [Internet]. 2022 June 29 [cited 2024 November 09];23(13). doi: 10.3390/ijms23137245

D. Krsnik, T. Marić, F. Bulić Jakuš, N. Sinčić and A. Katušić Bojanac, "LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging", International Journal of Molecular Sciences, vol. 23, no. 13, June 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:397288. [Accessed: 09 November 2024]

Metadata
Title (english)LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
AuthorDajana Krsnik
AuthorTihana Marić
AuthorFloriana Bulić-Jakuš
AuthorNino Sinčić
AuthorAna Katušić Bojanac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 23, no. 13, 7245
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23137245
URN:NBNurn:nbn:hr:105:397288
Publication2022-06-29
Document URLhttps://www.mdpi.com/1422-0067/23/13/7245
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-04-19 10:55:20