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LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
International Journal of Molecular Sciences, 23 (2022), 13; 7245. https://doi.org/10.3390/ijms23137245
Krsnik, Dajana; Marić, Tihana; Bulić-Jakuš, Floriana; Sinčić, Nino; Katušić Bojanac, Ana

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Krsnik, D., Marić, T., Bulić Jakuš, F., Sinčić, N. i Katušić Bojanac, A. (2022). LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging. International Journal of Molecular Sciences, 23. (13). doi: 10.3390/ijms23137245

Krsnik, Dajana, et al. "LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging." International Journal of Molecular Sciences, vol. 23, br. 13, 2022. https://doi.org/10.3390/ijms23137245

Krsnik, Dajana, Tihana Marić, Floriana Bulić Jakuš, Nino Sinčić i Ana Katušić Bojanac. "LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging." International Journal of Molecular Sciences 23, br. 13 (2022). https://doi.org/10.3390/ijms23137245

Krsnik, D., et al. (2022) 'LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging', International Journal of Molecular Sciences, 23(13). doi: 10.3390/ijms23137245

Krsnik D, Marić T, Bulić Jakuš F, Sinčić N, Katušić Bojanac A. LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging. International Journal of Molecular Sciences [Internet]. 29.06.2022. [pristupljeno 26.11.2024.];23(13). doi: 10.3390/ijms23137245

D. Krsnik, T. Marić, F. Bulić Jakuš, N. Sinčić i A. Katušić Bojanac, "LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging", International Journal of Molecular Sciences, vol. 23, br. 13, Lipanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:397288. [Citirano: 26.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:397288
Podaci o radu
Naslov (engleski)LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
AutorDajana Krsnik
AutorTihana Marić
AutorFloriana Bulić-Jakuš
AutorNino Sinčić
AutorAna Katušić Bojanac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 23, br. 13, 7245
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23137245
URN:NBNurn:nbn:hr:105:397288
Datum objave publikacije2022-06-29
URL dokumentahttps://www.mdpi.com/1422-0067/23/13/7245
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-04-19 10:55:20