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doctoral thesis
Povezanost izraženosti IGFBP-2 i IGFBP-5 s pokazateljima angiogeneze te njihov prognostički značaj kod glioblastoma
Zagreb: University of Zagreb, School of Medicine, 2011. urn:nbn:hr:105:815638
Pažanin, Leo
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Pažanin, L. (2011). Povezanost izraženosti IGFBP-2 i IGFBP-5 s pokazateljima angiogeneze te njihov prognostički značaj kod glioblastoma (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:815638

Pažanin, Leo. "Povezanost izraženosti IGFBP-2 i IGFBP-5 s pokazateljima angiogeneze te njihov prognostički značaj kod glioblastoma ." Doctoral thesis, University of Zagreb, School of Medicine, 2011. https://urn.nsk.hr/urn:nbn:hr:105:815638

Pažanin, Leo. "Povezanost izraženosti IGFBP-2 i IGFBP-5 s pokazateljima angiogeneze te njihov prognostički značaj kod glioblastoma ." Doctoral thesis, University of Zagreb, School of Medicine, 2011. https://urn.nsk.hr/urn:nbn:hr:105:815638

Pažanin, L. (2011). 'Povezanost izraženosti IGFBP-2 i IGFBP-5 s pokazateljima angiogeneze te njihov prognostički značaj kod glioblastoma ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 04 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:815638

Pažanin L. Povezanost izraženosti IGFBP-2 i IGFBP-5 s pokazateljima angiogeneze te njihov prognostički značaj kod glioblastoma [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2011 [cited 2024 December 04] Available at: https://urn.nsk.hr/urn:nbn:hr:105:815638

L. Pažanin, "Povezanost izraženosti IGFBP-2 i IGFBP-5 s pokazateljima angiogeneze te njihov prognostički značaj kod glioblastoma ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:105:815638

Metadata
TitlePovezanost izraženosti IGFBP-2 i IGFBP-5 s pokazateljima angiogeneze te njihov prognostički značaj kod glioblastoma
Title (english)Correlation of IGFBP-2 and IGFBP-5 expressions with the markers of angiogensis in glioblastoma and their prognostic significance
AuthorLeo Pažanin
MBZ: 194733
Mentor Majda Vučić (mentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2011-05-19, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Glioblastom je najzlocudniji, najbolje vaskularizirani i najcešci primarni tumor mozga. IGFBP-2 i IGFBP-5 proteini su koji, djelujuci samostalno ili u okviru IGF sustava, imaju znacajnu ulogu u zlocudnoj progresiji astroglijalnih tumora. Odnos izraženosti ovih proteina i VEGF-a upucuje na to da IGFBP-2 potice, a IGFBP-5 sprjecava angiogenezu. Na temelju toga može se pretpostaviti da izraženost IGFBP-2 pozitivno, a IGFBP-5 negativno korelira s gustocom novostvorenih tumorskih krvnih žila i morfološkim obrascem neovaskularizacije, te da ove korelacije u odnosu na preživljenje imaju prognosticki znacaj u oboljelih od glioblastoma. Kako bi se ispitala navedena hipoteza u ovom se radu na 56 patohistoloških uzoraka glioblastoma imunohistokemijskom metodom odredila izraženost IGFBP-2 i IGFBP-5, izmjerila se gustoca novostvorenih krvnih žila i odredio prevladavajuci obrazac neovaskularizacije. Dobiveni rezultati pokazuju da vecina glioblastoma pokazuje povecanu izraženost IGFBP-2 (75%), ali ne i IGFBP-5 (30%). Izraženost IGFBP-5 ne korelira ni s gustocom novostvorenih krvnih žila ni s morfološkim obrascem neovaskularizacije i nema prognostickog znacaja. Izraženost IGFBP-2 korelira s pojavom tumorskih pseudopalisada i s bizarnim obrascem neovaskularizacije. Statisticki znacajan utjecaj na preživljenje u univarijantnoj analizi imaju izraženost IGFBP-2 u >5% tumorskih stanica i prisutnost pseudopalisada, dok u multivarijantnoj analizi statisticki znacajan utjecaj na preživljenje imaju dob bolesnika i prisutnost pseudopalisada.
Abstract (english)
Glioblastoma is the most malignant, the best vascularised and the most frequent primary brain tumor. IGFBP-2 and IGFBP-5 through their IGFdependent and IGF-independent actions might have a significant role in anaplastic progression of astroglial tumors. The relationship between the expressions of these proteins and VEGF suggests the proangiogenic role for IGFBP-2 and antiangiogenic role for IGFBP-5. This is the basis for our hypothesis that IGFPB-2 expression positively and IGFBP-5 expression negatively correlate with the microvessel density and vascular patterns and that these correlations have prognostic impact in glioblastoma patients. To test this hypothesis we will immunohistochemically determine IGFBP-2 and IGFBP-5 expression, microvessel density and vascular patterns on 56 glioblastoma biopsy samples. Our results show IGFBP-2 expression in most glioblastomas (75%) and IGFBP- 5 expression in only 30% tumors. IGFBP-5 expression does not correlate with the microvessel density or with morphological pattern of neovascularisation and has no prognostic value. IGFBP- 2 expression correlates with the presence of palisading necrosis and with the presence of bizarre pattern of neovascularisation. IGFBP-2 immunoreactivity in more than 5% of tumor cells and the presence of palisading necrosis were prognostically significant in univariant analysis while in multivariant analysis only a patient’s age and the presence of palisading necrosis remained statistically significant.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:815638
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent86 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-05 07:01:24