prikaz prve stranice dokumenta Calretinin neurons in the primate prefrontal cortex
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doctoral thesis
Calretinin neurons in the primate prefrontal cortex
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:991608
Sedmak, Dora
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Sedmak, D. (2019). Calretinin neurons in the primate prefrontal cortex (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:991608

Sedmak, Dora. "Calretinin neurons in the primate prefrontal cortex ." Doctoral thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:991608

Sedmak, Dora. "Calretinin neurons in the primate prefrontal cortex ." Doctoral thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:991608

Sedmak, D. (2019). 'Calretinin neurons in the primate prefrontal cortex ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:991608

Sedmak D. Calretinin neurons in the primate prefrontal cortex [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:991608

D. Sedmak, "Calretinin neurons in the primate prefrontal cortex ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:991608

Metadata
TitleCalretinin neurons in the primate prefrontal cortex
Title (croatian)Kalretininski neuroni u prefrontalnom korteksu primata
AuthorDora Sedmak
MentorZdravko Petanjek (mentor)
MentorMonique Esclapez (komentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2019-05-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Neuronal circuitries of the cerebral cortex are the main biological substrates for mental abilities found in mammals. Diversity of primate synaptic architecture enable appearance of complex cognition and their disorganization leads to many neurological and behavioral disturbances. Substantial reorganization of cortical network occurring during primate evolution is necessary to achieve complex information processing. We performed systematic quantitative analysis in prefrontal cortical areas 9, 32 and 24 of monkey and human to determine the proportion, distribution and neurotransmitter phenotype of calretinin neurons, whose proportion dramatically increases when primates are compared to rodents. In primate brain up to 15% of neurons express calretinin and they are mostly positioned in upper cortical layers (up to 40% in layer II, and up to 70% in layer I). VGAT mRNA was found in all calretinin neurons, which directly confirmed their GABAergic phenotype. Double labeling showed that calretinin neurons are more numerous than other subpopulation of interneurons. This data suggest that GABAergic neurons in layer I and II of the primate associative areas outnumber the principal glutamatergic neurons. There were no areal differences in laminar distribution of calretinin neurons in the primate brain, but we found spatial reorganization inside the cortical lamina favoring the upper cortico-cortical layers and affecting higher order neocortical areas in monkey and all of human prefrontal cortical areas.
Abstract (croatian)
Pojava složenih moždanih funkcija u čovjeka mora biti odraz reorganizacije u strukturi neuralnih mreža kore velikog mozga. Promjene u sinaptičkoj arhitekturi primata su temelj razvoja viših kognitivnih funkcija, a narušena arhitektonika dovodi do neuroloških i psihijatrijskih poremećaja. Pretpostavlja se kako u evoluciji primata do najvećih promjena u strukturi neuralne mreže dolazi upravo u prefrontalnoj kori velikog mozga. Cilj ovog istraživanja je provesti sustavnu kvantitativnu analizu proporcije, distribucije i molekularnog fenotipa kalretininskih neurona kroz funkcionalno različita polja prefrontalnoga korteksa (Brodmanova polja 9, 32 i 24) u majmuna i čovjeka te utvrditi postoje li obilježja specifična za polje ili vrstu. U mozgu primata kalretininski neuroni čine 15% ukupnog broja neurona i većinom su smješteni u površnijim kortikalnim slojevima (40% u sloju II, 70% u sloju I). Pokazano je da svi kalretininski neuroni eksprimiraju VGAT mRNA što izravno potvrđuje njihov GABAergički fenotip. Dvostruko bojanje je pokazalo da su kalretininski neuroni brojniji od ostalih glavnih subpopulacija interneurona. Ovi podatci ukazuju da su GABAergički neuroni u slojevima I i II u asocijativnim područjima u primata jednako brojni kao i glutamatergički neuroni. Ne postoji razlika u njihovoj proporciji između majmuna i čovjeka niti između različitih moždanih polja unutar iste vrste. Može se zaključiti kako je tijekom evolucije primata došlo do reorganizacije laminarne strukture, tako da je veći broj neurona smješten u gornjim slojevima moždane kore koji su izvor kortiko-kortikalnih projekcija. Tendencija ovim promjenama vidljiva je između vrsta i između različitih polja unutar vrste, pa tako hijerarhijski viša područja imaju veći broj neurona u površnijim slojevima.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:991608
Study programmeTitle: Neuroscience
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent130 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-05 08:29:06