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Scientific paper - Original scientific paper
ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population
Annals of Human Biology, 49 (2022), 7-8; 323-331. https://doi.org/10.1080/03014460.2022.2140826
Božina, Tamara; Ganoci, Lana; Karačić, Ena; Šimičević, Livija; Vrkić-Kirhmajer, Majda; Klarica-Domjanović, Iva; Križ, Tena; Sertić, Zrinka; Božina, Nada

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Božina, T., Ganoci, L., Karačić, E., Šimičević, L., Vrkić Kirhmajer, M., Klarica Domjanović, I. ... Božina, N. (2022). ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population. Annals of Human Biology, 49. (7-8), 323-331. doi: 10.1080/03014460.2022.2140826

Božina, Tamara, et al. "ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population." Annals of Human Biology, vol. 49, no. 7-8, 2022, pp. 323-331. https://doi.org/10.1080/03014460.2022.2140826

Božina, Tamara, Lana Ganoci, Ena Karačić, Livija Šimičević, Majda Vrkić Kirhmajer, Iva Klarica Domjanović, Tena Križ, Zrinka Sertić and Nada Božina. "ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population." Annals of Human Biology 49, no. 7-8 (2022): 323-331. https://doi.org/10.1080/03014460.2022.2140826

Božina, T., et al. (2022) 'ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population', Annals of Human Biology, 49(7-8), pp. 323-331. doi: 10.1080/03014460.2022.2140826

Božina T, Ganoci L, Karačić E, Šimičević L, Vrkić Kirhmajer M, Klarica Domjanović I, and sur.. ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population. Annals of Human Biology [Internet]. 2022 December 09 [cited 2024 April 27];49(7-8):323-331. doi: 10.1080/03014460.2022.2140826

T. Božina, et al., "ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population", Annals of Human Biology, vol. 49, no. 7-8, pp. 323-331, December 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:438197. [Accessed: 27 April 2024]

Metadata
Title (english)ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population
AuthorTamara Božina
AuthorLana Ganoci
AuthorEna Karačić
AuthorLivija Šimičević
AuthorMajda Vrkić-Kirhmajer
AuthorIva Klarica-Domjanović
AuthorTena Križ
AuthorZrinka Sertić
AuthorNada Božina
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Background: Organic anion-transporting polypeptide 1B1 (OATP1B1) and the ATP-binding cassette subfamily G member 2, ABCG2, are important transporters involved in the transport of endogenous substrates and xenobiotics, including drugs. Genetic polymorphisms of these transporters have effect on transporter activity. There is significant interethnic variability in the frequency of allele variants. Aim: To determined allele and genotype frequencies of ABCG2 and SLCO1B1 genes in Croatian populations of European descent. Subjects and methods: A total of 905 subjects (482 women) were included. Genotyping for ABCG2 c.421C > A (rs2231142) and for SLCO1B1 c.521T > C (rs4149056), was performed by real-time polymerase chain reaction (PCR) using TaqMan® DME Genotyping Assays. Results: For ABCG2 c.421C > A, the frequency of CC, CA and AA genotypes was 81.4%, 17.8% and 0.8% respectively. The frequency of variant ABCG2 421 A allele was 9.7%. For SLCO1B1 c.521T > C, the frequency of TT, TC and CC genotypes was 61.7%, 34.8% and 3.5% respectively. The frequency of variant SLCO1B1 521 C allele was 20.9%. Conclusion: The frequency of the ABCG2 and SLCO1B1 allelic variants and genotypes in the Croatian population is in accordance with other European populations. Pharmacogenetic analysis can serve to individualise drug therapy and minimise the risk of developing adverse drug reactions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAnnals of Human Biology
Numberingvol. 49, no. 7-8, pp. 323-331
p-ISSN0301-4460
e-ISSN1464-5033
DOIhttps://doi.org/10.1080/03014460.2022.2140826
URN:NBNurn:nbn:hr:105:438197
Publication2022-12-09
Document URLhttps://www.tandfonline.com/doi/full/10.1080/03014460.2022.2140826
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-07-12 10:50:35