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ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population
Annals of Human Biology, 49 (2022), 7-8; 323-331. https://doi.org/10.1080/03014460.2022.2140826
Božina, Tamara; Ganoci, Lana; Karačić, Ena; Šimičević, Livija; Vrkić-Kirhmajer, Majda; Klarica-Domjanović, Iva; Križ, Tena; Sertić, Zrinka; Božina, Nada

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Božina, T., Ganoci, L., Karačić, E., Šimičević, L., Vrkić Kirhmajer, M., Klarica Domjanović, I. ... Božina, N. (2022). ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population. Annals of Human Biology, 49. (7-8), 323-331. doi: 10.1080/03014460.2022.2140826

Božina, Tamara, et al. "ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population." Annals of Human Biology, vol. 49, br. 7-8, 2022, str. 323-331. https://doi.org/10.1080/03014460.2022.2140826

Božina, Tamara, Lana Ganoci, Ena Karačić, Livija Šimičević, Majda Vrkić Kirhmajer, Iva Klarica Domjanović, Tena Križ, Zrinka Sertić i Nada Božina. "ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population." Annals of Human Biology 49, br. 7-8 (2022): 323-331. https://doi.org/10.1080/03014460.2022.2140826

Božina, T., et al. (2022) 'ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population', Annals of Human Biology, 49(7-8), str. 323-331. doi: 10.1080/03014460.2022.2140826

Božina T, Ganoci L, Karačić E, Šimičević L, Vrkić Kirhmajer M, Klarica Domjanović I, i sur.. ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population. Annals of Human Biology [Internet]. 09.12.2022. [pristupljeno 23.11.2024.];49(7-8):323-331. doi: 10.1080/03014460.2022.2140826

T. Božina, et al., "ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population", Annals of Human Biology, vol. 49, br. 7-8, str. 323-331, Prosinac 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:438197. [Citirano: 23.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:438197
Podaci o radu
Naslov (engleski)ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population
AutorTamara Božina
AutorLana Ganoci
AutorEna Karačić
AutorLivija Šimičević
AutorMajda Vrkić-Kirhmajer
AutorIva Klarica-Domjanović
AutorTena Križ
AutorZrinka Sertić
AutorNada Božina
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Background: Organic anion-transporting polypeptide 1B1 (OATP1B1) and the ATP-binding cassette subfamily G member 2, ABCG2, are important transporters involved in the transport of endogenous substrates and xenobiotics, including drugs. Genetic polymorphisms of these transporters have effect on transporter activity. There is significant interethnic variability in the frequency of allele variants. Aim: To determined allele and genotype frequencies of ABCG2 and SLCO1B1 genes in Croatian populations of European descent. Subjects and methods: A total of 905 subjects (482 women) were included. Genotyping for ABCG2 c.421C > A (rs2231142) and for SLCO1B1 c.521T > C (rs4149056), was performed by real-time polymerase chain reaction (PCR) using TaqMan® DME Genotyping Assays. Results: For ABCG2 c.421C > A, the frequency of CC, CA and AA genotypes was 81.4%, 17.8% and 0.8% respectively. The frequency of variant ABCG2 421 A allele was 9.7%. For SLCO1B1 c.521T > C, the frequency of TT, TC and CC genotypes was 61.7%, 34.8% and 3.5% respectively. The frequency of variant SLCO1B1 521 C allele was 20.9%. Conclusion: The frequency of the ABCG2 and SLCO1B1 allelic variants and genotypes in the Croatian population is in accordance with other European populations. Pharmacogenetic analysis can serve to individualise drug therapy and minimise the risk of developing adverse drug reactions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAnnals of Human Biology
Brojčani podacivol. 49, br. 7-8, str. 323-331
p-ISSN0301-4460
e-ISSN1464-5033
DOIhttps://doi.org/10.1080/03014460.2022.2140826
URN:NBNurn:nbn:hr:105:438197
Datum objave publikacije2022-12-09
URL dokumentahttps://www.tandfonline.com/doi/full/10.1080/03014460.2022.2140826
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-07-12 10:50:35