prikaz prve stranice dokumenta Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma
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Scientific paper - Original scientific paper
Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma
Croatian Medical Journal, 64 (2023), 2; 84-92. https://doi.org/10.3325/cmj.2023.64.84
Harabajsa, Suzana; Šefčić, Hajdi; Klasić, Marija; Milavić, Marija; Židovec Lepej, Snježana; Grgić, Ivana; Zajc Petranović, Matea; Jakopović, Marko; Smojver-Ježek, Silvana; Korać, Petra

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Harabajsa, S., Šefčić, H., Klasić, M., Milavić, M., Židovec Lepej, S., Grgić, I. ... Korać, P. (2023). Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma. Croatian Medical Journal, 64. (2), 84-92. doi: 10.3325/cmj.2023.64.84

Harabajsa, Suzana, et al. "Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma." Croatian Medical Journal, vol. 64, no. 2, 2023, pp. 84-92. https://doi.org/10.3325/cmj.2023.64.84

Harabajsa, Suzana, Hajdi Šefčić, Marija Klasić, Marija Milavić, Snježana Židovec Lepej, Ivana Grgić, Matea Zajc Petranović, Marko Jakopović, Silvana Smojver Ježek and Petra Korać. "Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma." Croatian Medical Journal 64, no. 2 (2023): 84-92. https://doi.org/10.3325/cmj.2023.64.84

Harabajsa, S., et al. (2023) 'Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma', Croatian Medical Journal, 64(2), pp. 84-92. doi: 10.3325/cmj.2023.64.84

Harabajsa S, Šefčić H, Klasić M, Milavić M, Židovec Lepej S, Grgić I, and sur.. Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma. Croatian Medical Journal [Internet]. 2023 April [cited 2024 November 04];64(2):84-92. doi: 10.3325/cmj.2023.64.84

S. Harabajsa, et al., "Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma", Croatian Medical Journal, vol. 64, no. 2, pp. 84-92, April 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:641754. [Accessed: 04 November 2024]

Metadata
Title (english)Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma
AuthorSuzana Harabajsa
AuthorHajdi Šefčić
AuthorMarija Klasić
AuthorMarija Milavić
AuthorSnježana Židovec Lepej
AuthorIvana Grgić
AuthorMatea Zajc Petranović
AuthorMarko Jakopović
AuthorSilvana Smojver-Ježek
AuthorPetra Korać
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aim: To assess the frequency of human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and high-risk types of human papillomavirus (HPV16 and HPV18) infections in lung adenocarcinoma samples. Methods: Lung adenocarcinoma cytological smears and their DNA isolates were obtained from patients hospitalized at the Department for Lung Diseases Jordanovac, Zagreb, in 2016 and 2017. Overall, 67 lung adenocarcinoma samples were examined: 34 with epidermal growth factor receptor gene (EGFR) mutations and 33 without EGFR mutations. The EGFR mutation status and virus presence were assessed with a polymerase chain reaction, and random samples were additionally tested for EBV with Sanger sequencing. HCMV, EBV, HPV16, and HPV18 infections were evaluated in relation to EGFR mutation, smoking status, and sex. A meta-analysis of available data about HPV infection in non-small cell lung cancer was performed. Results: More frequent HCMV, EBV, HPV16, and HPV18 infections were observed in lung adenocarcinoma samples with EGFR mutations than in samples without these mutations. Coinfection of the investigated viruses was observed only in lung adenocarcinoma samples with mutated EGFR. In the group with EGFR mutations, smoking was significantly associated with HPV16 infection. The meta-analysis showed that non-small cell lung cancer patients with EGFR mutations had a higher odds of HPV infection. Conclusion: HCMV, EBV, and high-risk HPV infections are more frequent in EGFR-mutated lung adenocarcinomas, which indicates a possible viral impact on the etiology of this lung cancer subtype.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 64, no. 2, pp. 84-92
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2023.64.84
URN:NBNurn:nbn:hr:105:641754
Publication2023-04
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183960/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-07-14 09:29:27