prikaz prve stranice dokumenta Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma
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Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma
Croatian Medical Journal, 64 (2023), 2; 84-92. https://doi.org/10.3325/cmj.2023.64.84
Harabajsa, Suzana; Šefčić, Hajdi; Klasić, Marija; Milavić, Marija; Židovec Lepej, Snježana; Grgić, Ivana; Zajc Petranović, Matea; Jakopović, Marko; Smojver-Ježek, Silvana; Korać, Petra

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Harabajsa, S., Šefčić, H., Klasić, M., Milavić, M., Židovec Lepej, S., Grgić, I. ... Korać, P. (2023). Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma. Croatian Medical Journal, 64. (2), 84-92. doi: 10.3325/cmj.2023.64.84

Harabajsa, Suzana, et al. "Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma." Croatian Medical Journal, vol. 64, br. 2, 2023, str. 84-92. https://doi.org/10.3325/cmj.2023.64.84

Harabajsa, Suzana, Hajdi Šefčić, Marija Klasić, Marija Milavić, Snježana Židovec Lepej, Ivana Grgić, Matea Zajc Petranović, Marko Jakopović, Silvana Smojver Ježek i Petra Korać. "Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma." Croatian Medical Journal 64, br. 2 (2023): 84-92. https://doi.org/10.3325/cmj.2023.64.84

Harabajsa, S., et al. (2023) 'Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma', Croatian Medical Journal, 64(2), str. 84-92. doi: 10.3325/cmj.2023.64.84

Harabajsa S, Šefčić H, Klasić M, Milavić M, Židovec Lepej S, Grgić I, i sur.. Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma. Croatian Medical Journal [Internet]. 04.2023. [pristupljeno 06.11.2024.];64(2):84-92. doi: 10.3325/cmj.2023.64.84

S. Harabajsa, et al., "Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma", Croatian Medical Journal, vol. 64, br. 2, str. 84-92, Travanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:641754. [Citirano: 06.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:641754
Podaci o radu
Naslov (engleski)Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma
AutorSuzana Harabajsa
AutorHajdi Šefčić
AutorMarija Klasić
AutorMarija Milavić
AutorSnježana Židovec Lepej
AutorIvana Grgić
AutorMatea Zajc Petranović
AutorMarko Jakopović
AutorSilvana Smojver-Ježek
AutorPetra Korać
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Aim: To assess the frequency of human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and high-risk types of human papillomavirus (HPV16 and HPV18) infections in lung adenocarcinoma samples. Methods: Lung adenocarcinoma cytological smears and their DNA isolates were obtained from patients hospitalized at the Department for Lung Diseases Jordanovac, Zagreb, in 2016 and 2017. Overall, 67 lung adenocarcinoma samples were examined: 34 with epidermal growth factor receptor gene (EGFR) mutations and 33 without EGFR mutations. The EGFR mutation status and virus presence were assessed with a polymerase chain reaction, and random samples were additionally tested for EBV with Sanger sequencing. HCMV, EBV, HPV16, and HPV18 infections were evaluated in relation to EGFR mutation, smoking status, and sex. A meta-analysis of available data about HPV infection in non-small cell lung cancer was performed. Results: More frequent HCMV, EBV, HPV16, and HPV18 infections were observed in lung adenocarcinoma samples with EGFR mutations than in samples without these mutations. Coinfection of the investigated viruses was observed only in lung adenocarcinoma samples with mutated EGFR. In the group with EGFR mutations, smoking was significantly associated with HPV16 infection. The meta-analysis showed that non-small cell lung cancer patients with EGFR mutations had a higher odds of HPV infection. Conclusion: HCMV, EBV, and high-risk HPV infections are more frequent in EGFR-mutated lung adenocarcinomas, which indicates a possible viral impact on the etiology of this lung cancer subtype.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 64, br. 2, str. 84-92
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2023.64.84
URN:NBNurn:nbn:hr:105:641754
Datum objave publikacije2023-04
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183960/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2023-07-14 09:29:27