prikaz prve stranice dokumenta Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis
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Scientific paper - Original scientific paper
Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis
Journal of Clinical Medicine, 11 (2022), 19; 5907. https://doi.org/10.3390/jcm11195907
Domislović, Viktor; Høg Mortensen, Joachim; Lindholm, Majken; Kaarsdal, Morten Asser; Brinar, Marko; Barišić, Ana; Manon-Jensen, Tina; Krznarić, Željko

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Domislović, V., Høg Mortensen, J., Lindholm, M., Kaarsdal, M. A., Brinar, M., Barišić, A. ... Krznarić, Ž. (2022). Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis. Journal of Clinical Medicine, 11. (19). doi: 10.3390/jcm11195907

Domislović, Viktor, et al. "Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis." Journal of Clinical Medicine, vol. 11, no. 19, 2022. https://doi.org/10.3390/jcm11195907

Domislović, Viktor, Joachim Høg Mortensen, Majken Lindholm, Morten Asser Kaarsdal, Marko Brinar, Ana Barišić, Tina Manon Jensen and Željko Krznarić. "Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis." Journal of Clinical Medicine 11, no. 19 (2022). https://doi.org/10.3390/jcm11195907

Domislović, V., et al. (2022) 'Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis', Journal of Clinical Medicine, 11(19). doi: 10.3390/jcm11195907

Domislović V, Høg Mortensen J, Lindholm M, Kaarsdal MA, Brinar M, Barišić A, and sur.. Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis. Journal of Clinical Medicine [Internet]. 2022 October 07 [cited 2024 April 30];11(19). doi: 10.3390/jcm11195907

V. Domislović, et al., "Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis", Journal of Clinical Medicine, vol. 11, no. 19, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:234226. [Accessed: 30 April 2024]

Metadata
Title (english)Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis
AuthorViktor Domislović
AuthorJoachim Høg Mortensen
AuthorMajken Lindholm
AuthorMorten Asser Kaarsdal
AuthorMarko Brinar
AuthorAna Barišić
AuthorTina Manon-Jensen
AuthorŽeljko Krznarić
MBZ: 75865
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Extracellular matrix (ECM) homeostasis is highly affected in active inflammatory bowel disease (IBD). The aim of the study was to investigate serological biomarkers of type III, IV, and V collagen degradation and formation, and their association with disease activity in IBD. ECM remodeling serum biomarkers were measured in 162 IBD patients, 110 with Crohn’s disease (CD) and 52 with ulcerative colitis (UC), and in 29 healthy donors. Biomarkers of type III collagen degradation (C3M) and formation (PRO-C3), type IV collagen degradation (C4M) and formation (PRO-C4), and type V collagen formation (PRO-C5) were measured using ELISA. Inflammatory activity was assessed using endoscopic, clinical, and biochemical activity indices. The highest diagnostic value was identified in discriminating endoscopically moderate to severe disease in CD (PRO-C3, C3M/PRO-C3, and C4M with AUC of 0.70, 0.73, and 0.69, respectively) and UC (C3M, C3M/PRO-C3, and C4M with AUC of 0.86, 0.80, and 0.76, respectively). C4M and C3M/PRO-C3 in combination yielded AUC of 0.93 (0.66–0.90) in CD and 0.94 (0.65–0.99) in UC. This study confirmed that ECM remodeling reflected disease activity in CD and UC. A combination of C4M, C3M, and PRO-C3 biomarkers may potentially be considered as a biomarker differentiating moderate to severe endoscopic disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 11, no. 19, 5907
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm11195907
URN:NBNurn:nbn:hr:105:234226
Publication2022-10-07
Document URLhttps://www.mdpi.com/2077-0383/11/19/5907
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-08-22 08:04:18