prikaz prve stranice dokumenta Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis
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Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis
Journal of Clinical Medicine, 11 (2022), 19; 5907. https://doi.org/10.3390/jcm11195907
Domislović, Viktor; Høg Mortensen, Joachim; Lindholm, Majken; Kaarsdal, Morten Asser; Brinar, Marko; Barišić, Ana; Manon-Jensen, Tina; Krznarić, Željko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Domislović, V., Høg Mortensen, J., Lindholm, M., Kaarsdal, M. A., Brinar, M., Barišić, A. ... Krznarić, Ž. (2022). Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis. Journal of Clinical Medicine, 11. (19). doi: 10.3390/jcm11195907

Domislović, Viktor, et al. "Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis." Journal of Clinical Medicine, vol. 11, br. 19, 2022. https://doi.org/10.3390/jcm11195907

Domislović, Viktor, Joachim Høg Mortensen, Majken Lindholm, Morten Asser Kaarsdal, Marko Brinar, Ana Barišić, Tina Manon Jensen i Željko Krznarić. "Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis." Journal of Clinical Medicine 11, br. 19 (2022). https://doi.org/10.3390/jcm11195907

Domislović, V., et al. (2022) 'Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis', Journal of Clinical Medicine, 11(19). doi: 10.3390/jcm11195907

Domislović V, Høg Mortensen J, Lindholm M, Kaarsdal MA, Brinar M, Barišić A, i sur.. Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis. Journal of Clinical Medicine [Internet]. 07.10.2022. [pristupljeno 13.05.2024.];11(19). doi: 10.3390/jcm11195907

V. Domislović, et al., "Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis", Journal of Clinical Medicine, vol. 11, br. 19, Listopad 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:234226. [Citirano: 13.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:234226
Podaci o radu
Naslov (engleski)Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis
AutorViktor Domislović
AutorJoachim Høg Mortensen
AutorMajken Lindholm
AutorMorten Asser Kaarsdal
AutorMarko Brinar
AutorAna Barišić
AutorTina Manon-Jensen
AutorŽeljko Krznarić
MBZ: 75865
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Extracellular matrix (ECM) homeostasis is highly affected in active inflammatory bowel disease (IBD). The aim of the study was to investigate serological biomarkers of type III, IV, and V collagen degradation and formation, and their association with disease activity in IBD. ECM remodeling serum biomarkers were measured in 162 IBD patients, 110 with Crohn’s disease (CD) and 52 with ulcerative colitis (UC), and in 29 healthy donors. Biomarkers of type III collagen degradation (C3M) and formation (PRO-C3), type IV collagen degradation (C4M) and formation (PRO-C4), and type V collagen formation (PRO-C5) were measured using ELISA. Inflammatory activity was assessed using endoscopic, clinical, and biochemical activity indices. The highest diagnostic value was identified in discriminating endoscopically moderate to severe disease in CD (PRO-C3, C3M/PRO-C3, and C4M with AUC of 0.70, 0.73, and 0.69, respectively) and UC (C3M, C3M/PRO-C3, and C4M with AUC of 0.86, 0.80, and 0.76, respectively). C4M and C3M/PRO-C3 in combination yielded AUC of 0.93 (0.66–0.90) in CD and 0.94 (0.65–0.99) in UC. This study confirmed that ECM remodeling reflected disease activity in CD and UC. A combination of C4M, C3M, and PRO-C3 biomarkers may potentially be considered as a biomarker differentiating moderate to severe endoscopic disease.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 11, br. 19, 5907
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm11195907
URN:NBNurn:nbn:hr:105:234226
Datum objave publikacije2022-10-07
URL dokumentahttps://www.mdpi.com/2077-0383/11/19/5907
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-08-22 08:04:18