prikaz prve stranice dokumenta Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography
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Scientific paper - Original scientific paper
Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography
Ultraschall in der Medizin - European Journal of Ultrasound, 44 (2022), 02; 169-178. https://doi.org/10.1055/a-1724-7289
Bauer, David JM; Matić, Vladimir; Mare, Ruxandra; Maiocchi, Laura; Chromy, David; Müllner-Bucsics, Theresa; Mandorfer, Mattias; Mustapić, Sandra; Sporea, Ioan; Ferraioli, Giovanna; Grgurević, Ivica; Reiberger, Thomas

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Bauer, D. J., Matić, V., Mare, R., Maiocchi, L., Chromy, D., Müllner Bucsics, T. ... Reiberger, T. (2022). Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography. Ultraschall in der Medizin - European Journal of Ultrasound, 44. (02), 169-178. doi: 10.1055/a-1724-7289

Bauer, David JM, et al. "Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography." Ultraschall in der Medizin - European Journal of Ultrasound, vol. 44, no. 02, 2022, pp. 169-178. https://doi.org/10.1055/a-1724-7289

Bauer, David JM, Vladimir Matić, Ruxandra Mare, Laura Maiocchi, David Chromy, Theresa Müllner Bucsics, Mattias Mandorfer, et al. "Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography." Ultraschall in der Medizin - European Journal of Ultrasound 44, no. 02 (2022): 169-178. https://doi.org/10.1055/a-1724-7289

Bauer, D. J., et al. (2022) 'Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography', Ultraschall in der Medizin - European Journal of Ultrasound, 44(02), pp. 169-178. doi: 10.1055/a-1724-7289

Bauer DJ, Matić V, Mare R, Maiocchi L, Chromy D, Müllner Bucsics T, and sur.. Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography. Ultraschall in der Medizin - European Journal of Ultrasound [Internet]. 2022 February 28 [cited 2024 May 05];44(02):169-178. doi: 10.1055/a-1724-7289

D. J. Bauer, et al., "Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography", Ultraschall in der Medizin - European Journal of Ultrasound, vol. 44, no. 02, pp. 169-178, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:708121. [Accessed: 05 May 2024]

Metadata
Title (english)Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography
AuthorDavid JM Bauer
AuthorVladimir Matić
MBZ: 142564
AuthorRuxandra Mare
AuthorLaura Maiocchi
AuthorDavid Chromy
AuthorTheresa Müllner-Bucsics
AuthorMattias Mandorfer
AuthorSandra Mustapić
AuthorIoan Sporea
AuthorGiovanna Ferraioli
AuthorIvica Grgurević
AuthorThomas Reiberger
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: Since nonalcoholic fatty liver disease (NAFLD) has become the leading cause of liver disease in the Western world, clinicians need reliable noninvasive tools for the identification of NAFLD-associated fibrosis. Limited evidence on the performance of the novel shear wave elastography technique Elast-PQ (EPQ) in NAFLD is available. Method: In this prospective, European multinational study we assessed the diagnostic accuracy of EPQ using vibration-controlled transient elastography (VCTE) as a reference standard. Results: Among 353 NAFLD patients, 332 (94.1%) fulfilled reliability criteria of VCTE and EPQ (defined by IQR/median ≤0.3; 41.3% female, mean age: 59 [IQR: 16.5], mean BMI: 29.0 (7.1)). 4/353 (1.1%) and 17/353 (4.8%) had unreliable VCTE and EPQ measurements, respectively. VCTE-based NAFLD fibrosis stages were F0/F1: 222(66.9%), F2: 41 (12.3%), F3: 30 (9.1%), F4: 39 (11.7%). We found a strong correlation (Pearson R=0.87; p<0.0001) and concordance (Lin's concordance correlation coefficient =0.792) of EPQ with VCTE. EPQ was able to identify NAFLD-fibrosis risk with the following EPQ cutoffs: ≥6.5 kPa for significant fibrosis (≥F2) (≥1.47 m/s; sensitivity: 78%; specificity: 95%; AUROC: 0.94), ≥6.9 kPa for advanced fibrosis (≥F3) (≥1.52 m/s; sens.: 88%, spec.: 89%; AUROC: 0.949), and ≥10.4 kPa for cirrhosis (F4) (≥1.86 m/s; sens.: 87%; spec.: 94%; AUROC: 0.949). Conclusion: The point shear wave elastography technique EPQ shows excellent correlation to and concordance with VCTE. EPQ can reliably exclude NAFLD fibrosis <6.0 kPa (<1.41 m/s) and indicate a high risk of advanced fibrosis ≥10.4 kPa (≥1.86 m/s).
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleUltraschall in der Medizin - European Journal of Ultrasound
Numberingvol. 44, no. 02, pp. 169-178
p-ISSN0172-4614
e-ISSN1438-8782
DOIhttps://doi.org/10.1055/a-1724-7289
URN:NBNurn:nbn:hr:105:708121
Publication2022-02-28
Document URLhttp://www.thieme-connect.de/DOI/DOI?10.1055/a-1724-7289
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-08-31 08:22:31