prikaz prve stranice dokumenta Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
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Scientific paper - Original scientific paper
Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
Biomolecules, 13 (2023), 5; 800. https://doi.org/10.3390/biom13050800
Konjevod, Marcela; Sreter, Katherina B.; Popović-Grle, Sanja; Lampalo, Marina; Tudor, Lucija; Jukić, Irena; Nedić Erjavec, Gordana; Bingulac-Popović, Jasna; Safić Stanić, Hana; Nikolac Perković, Matea; Markeljević, Jasenka; Samaržija, Miroslav; Pivac, Nela; Švob Štrac, Dubravka

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Konjevod, M., Sreter, K. B., Popović Grle, S., Lampalo, M., Tudor, L., Jukić, I. ... Švob Štrac, D. (2023). Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules, 13. (5). doi: 10.3390/biom13050800

Konjevod, Marcela, et al. "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma." Biomolecules, vol. 13, no. 5, 2023. https://doi.org/10.3390/biom13050800

Konjevod, Marcela, Katherina B. Sreter, Sanja Popović Grle, Marina Lampalo, Lucija Tudor, Irena Jukić, Gordana Nedić Erjavec, et al. "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma." Biomolecules 13, no. 5 (2023). https://doi.org/10.3390/biom13050800

Konjevod, M., et al. (2023) 'Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma', Biomolecules, 13(5). doi: 10.3390/biom13050800

Konjevod M, Sreter KB, Popović Grle S, Lampalo M, Tudor L, Jukić I, and sur.. Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules [Internet]. 2023 May 08 [cited 2024 April 27];13(5). doi: 10.3390/biom13050800

M. Konjevod, et al., "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma", Biomolecules, vol. 13, no. 5, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:688010. [Accessed: 27 April 2024]

Metadata
Title (english)Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
AuthorMarcela Konjevod
AuthorKatherina B. Sreter
AuthorSanja Popović-Grle
AuthorMarina Lampalo
AuthorLucija Tudor
AuthorIrena Jukić
AuthorGordana Nedić Erjavec
AuthorJasna Bingulac-Popović
AuthorHana Safić Stanić
AuthorMatea Nikolac Perković
AuthorJasenka Markeljević
AuthorMiroslav Samaržija
AuthorNela Pivac
AuthorDubravka Švob Štrac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. Our study investigated platelet serotonin (5-HT) levels and platelet monoamine oxidase B (MAO-B) activity, as well as associations with HTR2A (rs6314; rs6313), HTR2C (rs3813929; rs518147), and MAOB (rs1799836; rs6651806) gene polymorphisms in 120 healthy individuals and 120 asthma patients of different severity and phenotypes. Platelet 5-HT concentration was significantly lower, while platelet MAO-B activity was considerably higher in asthma patients; however, they did not differ between patients with different asthma severity or phenotypes. Only the healthy subjects, but not the asthma patients, carrying the MAOB rs1799836 TT genotype had significantly lower platelet MAO-B activity than the C allele carriers. No significant differences in the frequency of the genotypes, alleles, or haplotypes for any of the investigated HTR2A, HTR2C and MAOB gene polymorphisms have been observed between asthma patients and healthy subjects or between patients with various asthma phenotypes. However, the carriers of the HTR2C rs518147 CC genotype or C allele were significantly less frequent in severe asthma patients than in the G allele carriers. Further studies are necessary to elucidate the involvement of the serotonergic system in asthma pathophysiology.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 13, no. 5, 800
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13050800
URN:NBNurn:nbn:hr:105:688010
Publication2023-05-08
Document URLhttps://www.mdpi.com/2218-273X/13/5/800
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-10-16 11:56:52