prikaz prve stranice dokumenta Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
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Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
Biomolecules, 13 (2023), 5; 800. https://doi.org/10.3390/biom13050800
Konjevod, Marcela; Sreter, Katherina B.; Popović-Grle, Sanja; Lampalo, Marina; Tudor, Lucija; Jukić, Irena; Nedić Erjavec, Gordana; Bingulac-Popović, Jasna; Safić Stanić, Hana; Nikolac Perković, Matea; Markeljević, Jasenka; Samaržija, Miroslav; Pivac, Nela; Švob Štrac, Dubravka

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Konjevod, M., Sreter, K. B., Popović Grle, S., Lampalo, M., Tudor, L., Jukić, I. ... Švob Štrac, D. (2023). Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules, 13. (5). doi: 10.3390/biom13050800

Konjevod, Marcela, et al. "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma." Biomolecules, vol. 13, br. 5, 2023. https://doi.org/10.3390/biom13050800

Konjevod, Marcela, Katherina B. Sreter, Sanja Popović Grle, Marina Lampalo, Lucija Tudor, Irena Jukić, Gordana Nedić Erjavec, et al. "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma." Biomolecules 13, br. 5 (2023). https://doi.org/10.3390/biom13050800

Konjevod, M., et al. (2023) 'Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma', Biomolecules, 13(5). doi: 10.3390/biom13050800

Konjevod M, Sreter KB, Popović Grle S, Lampalo M, Tudor L, Jukić I, i sur.. Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules [Internet]. 08.05.2023. [pristupljeno 05.11.2024.];13(5). doi: 10.3390/biom13050800

M. Konjevod, et al., "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma", Biomolecules, vol. 13, br. 5, Svibanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:688010. [Citirano: 05.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:688010
Podaci o radu
Naslov (engleski)Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
AutorMarcela Konjevod
AutorKatherina B. Sreter
AutorSanja Popović-Grle
AutorMarina Lampalo
AutorLucija Tudor
AutorIrena Jukić
AutorGordana Nedić Erjavec
AutorJasna Bingulac-Popović
AutorHana Safić Stanić
AutorMatea Nikolac Perković
AutorJasenka Markeljević
AutorMiroslav Samaržija
AutorNela Pivac
AutorDubravka Švob Štrac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
The complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. Our study investigated platelet serotonin (5-HT) levels and platelet monoamine oxidase B (MAO-B) activity, as well as associations with HTR2A (rs6314; rs6313), HTR2C (rs3813929; rs518147), and MAOB (rs1799836; rs6651806) gene polymorphisms in 120 healthy individuals and 120 asthma patients of different severity and phenotypes. Platelet 5-HT concentration was significantly lower, while platelet MAO-B activity was considerably higher in asthma patients; however, they did not differ between patients with different asthma severity or phenotypes. Only the healthy subjects, but not the asthma patients, carrying the MAOB rs1799836 TT genotype had significantly lower platelet MAO-B activity than the C allele carriers. No significant differences in the frequency of the genotypes, alleles, or haplotypes for any of the investigated HTR2A, HTR2C and MAOB gene polymorphisms have been observed between asthma patients and healthy subjects or between patients with various asthma phenotypes. However, the carriers of the HTR2C rs518147 CC genotype or C allele were significantly less frequent in severe asthma patients than in the G allele carriers. Further studies are necessary to elucidate the involvement of the serotonergic system in asthma pathophysiology.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 13, br. 5, 800
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13050800
URN:NBNurn:nbn:hr:105:688010
Datum objave publikacije2023-05-08
URL dokumentahttps://www.mdpi.com/2218-273X/13/5/800
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-10-16 11:56:52