prikaz prve stranice dokumenta Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer
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Scientific paper - Original scientific paper
Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer
International Journal of Molecular Sciences, 24 (2023), 9; 7698. https://doi.org/10.3390/ijms24097698
Anić, Petra; Golubić Talić, Jasminka; Božinović, Ksenija; Dediol, Emil; Mravak-Stipetić, Marinka; Grce, Magdalena; Milutin Gašperov, Nina

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Anić, P., Golubić Talić, J., Božinović, K., Dediol, E., Mravak Stipetić, M., Grce, M. & Milutin Gašperov, N. (2023). Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer. International Journal of Molecular Sciences, 24. (9). doi: 10.3390/ijms24097698

Anić, Petra, et al. "Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer." International Journal of Molecular Sciences, vol. 24, no. 9, 2023. https://doi.org/10.3390/ijms24097698

Anić, Petra, Jasminka Golubić Talić, Ksenija Božinović, Emil Dediol, Marinka Mravak Stipetić, Magdalena Grce and Nina Milutin Gašperov. "Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer." International Journal of Molecular Sciences 24, no. 9 (2023). https://doi.org/10.3390/ijms24097698

Anić, P., et al. (2023) 'Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer', International Journal of Molecular Sciences, 24(9). doi: 10.3390/ijms24097698

Anić P, Golubić Talić J, Božinović K, Dediol E, Mravak Stipetić M, Grce M, and sur.. Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer. International Journal of Molecular Sciences [Internet]. 2023 April 22 [cited 2024 November 04];24(9). doi: 10.3390/ijms24097698

P. Anić, et al., "Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer", International Journal of Molecular Sciences, vol. 24, no. 9, April 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:609986. [Accessed: 04 November 2024]

Metadata
Title (english)Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer
AuthorPetra Anić
AuthorJasminka Golubić Talić
AuthorKsenija Božinović
AuthorEmil Dediol
AuthorMarinka Mravak-Stipetić
AuthorMagdalena Grce
AuthorNina Milutin Gašperov
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Maxillofacial Surgery and Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
The proportion of oral and oropharyngeal squamous cell carcinoma (OOSCC) that can be attributed to human papillomavirus (HPV) infection is growing nowadays. A potential factor indicating the occurrence of HPV-positive OSCC is a change in the degree of methylation of gene promoters that play a key role in the immune response. In this study, we investigated the difference in the methylation of EDARADD, GBP4, HAVCR2, HLA DPB1, IL12RB1, MARCO, and SIGLEC12 gene promoters in samples of healthy oral mucosa versus samples of oral and oropharyngeal cancer. The presence of HPV infection in samples was examined earlier. To determine the difference in methylation of those gene promotors, isolated and bisulfite-modified DNA was analysed by the methylation-specific PCR method. The investigated gene promoters were found to be more hypomethylated in the oral and oropharyngeal cancer samples in comparison to normal tissue. The proportion of unmethylated gene promoters was similar in HPV-positive and HPV-negative cancers, although the data should be confirmed on a larger set of samples. To conclude, in samples of healthy oral mucosa, the investigated gene promoters were found to be methylated in a high percentage (73.3% to 100%), while in oral and oropharyngeal cancer samples, they were methylated in a low percentage (11.1% to 37%), regardless of HPV infection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 9, 7698
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24097698
URN:NBNurn:nbn:hr:105:609986
Publication2023-04-22
ProjectNumber: IP-2013-11-4758
Title (croatian): Epigenetičke promjene karcinoma pločastih stanica glave i vrata
Title (english): Epigenetic changes in head and neck squamous cell carcinoma
Acronym: EpiC-HNSCC
Leader: Magdalena Grce
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.mdpi.com/1422-0067/24/9/7698
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-11-02 09:19:38