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Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer
International Journal of Molecular Sciences, 24 (2023), 9; 7698. https://doi.org/10.3390/ijms24097698
Anić, Petra; Golubić Talić, Jasminka; Božinović, Ksenija; Dediol, Emil; Mravak-Stipetić, Marinka; Grce, Magdalena; Milutin Gašperov, Nina

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Anić, P., Golubić Talić, J., Božinović, K., Dediol, E., Mravak Stipetić, M., Grce, M. i Milutin Gašperov, N. (2023). Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer. International Journal of Molecular Sciences, 24. (9). doi: 10.3390/ijms24097698

Anić, Petra, et al. "Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer." International Journal of Molecular Sciences, vol. 24, br. 9, 2023. https://doi.org/10.3390/ijms24097698

Anić, Petra, Jasminka Golubić Talić, Ksenija Božinović, Emil Dediol, Marinka Mravak Stipetić, Magdalena Grce i Nina Milutin Gašperov. "Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer." International Journal of Molecular Sciences 24, br. 9 (2023). https://doi.org/10.3390/ijms24097698

Anić, P., et al. (2023) 'Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer', International Journal of Molecular Sciences, 24(9). doi: 10.3390/ijms24097698

Anić P, Golubić Talić J, Božinović K, Dediol E, Mravak Stipetić M, Grce M, i sur.. Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer. International Journal of Molecular Sciences [Internet]. 22.04.2023. [pristupljeno 05.05.2024.];24(9). doi: 10.3390/ijms24097698

P. Anić, et al., "Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer", International Journal of Molecular Sciences, vol. 24, br. 9, Travanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:609986. [Citirano: 05.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:609986
Podaci o radu
Naslov (engleski)Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer
AutorPetra Anić
AutorJasminka Golubić Talić
AutorKsenija Božinović
AutorEmil Dediol
AutorMarinka Mravak-Stipetić
AutorMagdalena Grce
AutorNina Milutin Gašperov
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MAKSILOFACIJALNU KIRURGIJU SA STOMATOLOGIJOM)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
The proportion of oral and oropharyngeal squamous cell carcinoma (OOSCC) that can be attributed to human papillomavirus (HPV) infection is growing nowadays. A potential factor indicating the occurrence of HPV-positive OSCC is a change in the degree of methylation of gene promoters that play a key role in the immune response. In this study, we investigated the difference in the methylation of EDARADD, GBP4, HAVCR2, HLA DPB1, IL12RB1, MARCO, and SIGLEC12 gene promoters in samples of healthy oral mucosa versus samples of oral and oropharyngeal cancer. The presence of HPV infection in samples was examined earlier. To determine the difference in methylation of those gene promotors, isolated and bisulfite-modified DNA was analysed by the methylation-specific PCR method. The investigated gene promoters were found to be more hypomethylated in the oral and oropharyngeal cancer samples in comparison to normal tissue. The proportion of unmethylated gene promoters was similar in HPV-positive and HPV-negative cancers, although the data should be confirmed on a larger set of samples. To conclude, in samples of healthy oral mucosa, the investigated gene promoters were found to be methylated in a high percentage (73.3% to 100%), while in oral and oropharyngeal cancer samples, they were methylated in a low percentage (11.1% to 37%), regardless of HPV infection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 9, 7698
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24097698
URN:NBNurn:nbn:hr:105:609986
Datum objave publikacije2023-04-22
ProjektŠifra: IP-2013-11-4758
Naziv (hrvatski): Epigenetičke promjene karcinoma pločastih stanica glave i vrata
Naziv (engleski): Epigenetic changes in head and neck squamous cell carcinoma
Kratica: EpiC-HNSCC
Voditelj: Magdalena Grce
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/1422-0067/24/9/7698
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-11-02 09:19:38