prikaz prve stranice dokumenta Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients
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Scientific paper - Original scientific paper
Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients
Wiener klinische Wochenschrift, 135 (2023), 9-10; 235-243. https://doi.org/10.1007/s00508-023-02180-w
Salai, Grgur; Vražić, Hrvoje; Kovačević, Ivona; Malnar Janeš, Linda; Marasović, Ivan; Ranilović, Darjan; Vukoja, Damir; Zelenika Margeta, Marina; Huljev–ŠipoŠ, Ivana; Lalić, Kristina; Špoljarić, Marko; Tekavec-Trkanjec, Jasna; Vergles, Mirna; Lucijanić, Marko; Lukšić, Ivica; Ljubičić, Đivo More authors...

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Salai, G., Vražić, H., Kovačević, I., Malnar Janeš, L., Marasović, I., Ranilović, D. ... Ljubičić, Đ. (2023). Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients. Wiener klinische Wochenschrift, 135. (9-10), 235-243. doi: 10.1007/s00508-023-02180-w

Salai, Grgur, et al. "Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients." Wiener klinische Wochenschrift, vol. 135, no. 9-10, 2023, pp. 235-243. https://doi.org/10.1007/s00508-023-02180-w

Salai, Grgur, Hrvoje Vražić, Ivona Kovačević, Linda Malnar Janeš, Ivan Marasović, Darjan Ranilović, Damir Vukoja, et al. "Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients." Wiener klinische Wochenschrift 135, no. 9-10 (2023): 235-243. https://doi.org/10.1007/s00508-023-02180-w

Salai, G., et al. (2023) 'Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients', Wiener klinische Wochenschrift, 135(9-10), pp. 235-243. doi: 10.1007/s00508-023-02180-w

Salai G, Vražić H, Kovačević I, Malnar Janeš L, Marasović I, Ranilović D, and sur.. Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients. Wiener klinische Wochenschrift [Internet]. 2023 May [cited 2024 November 23];135(9-10):235-243. doi: 10.1007/s00508-023-02180-w

G. Salai, et al., "Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients", Wiener klinische Wochenschrift, vol. 135, no. 9-10, pp. 235-243, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:101032. [Accessed: 23 November 2024]

Metadata
Title (english)Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients
AuthorGrgur Salai
AuthorHrvoje Vražić
AuthorIvona Kovačević
AuthorLinda Malnar Janeš
AuthorIvan Marasović
AuthorDarjan Ranilović
AuthorDamir Vukoja
AuthorMarina Zelenika Margeta
AuthorIvana Huljev–ŠipoŠ
AuthorKristina Lalić
AuthorMarko Špoljarić
AuthorJasna Tekavec-Trkanjec
AuthorMirna Vergles
AuthorMarko Lucijanić
AuthorIvica Lukšić
AuthorĐivo Ljubičić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Maxillofacial Surgery and Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Introduction: The impact of asthma and chronic obstructive pulmonary disease (COPD) in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) infection is not clearly defined. Blood eosinophil count is a standard diagnostic test which, according to the previously published literature, might have a potential prognostic role on mortality in patients with SARS-CoV‑2 infection. Aim: To investigate the potential prognostic value of peripheral blood eosinophil count on all-cause mortality of patients hospitalized with SARS-CoV‑2 infection, as well as to assess the impact of asthma or COPD premorbidity on all-cause mortality. Material and methods: We conducted a retrospective registry-based cohort study. Survival analysis was performed by employing the Cox proportional hazards regression model at 30 days of follow-up. Prognostic value of eosinophil count on all-cause mortality was assessed using receiver-operating characteristic (ROC) curve analysis. Results: A total of 5653 participants were included in the study. Our model did not reveal that pre-existing asthma or COPD is a statistically significant covariate for all-cause mortality but, indicated that higher eosinophil count at admission might have a protective effect (hazard ratio, HR 0.13 (95% confidence interval, CI 0.06-0.27), p = 0.0001). ROC curve analysis indicates cut-off value of 20 cells/mm3 (81% specificity; 30.9% sensitivity). Conclusion: Our results indicate that eosinophil count at hospital admission might have a potential prognostic role for all-cause mortality at 30 days of follow-up; however this was not demonstrated for pre-existing obstructive lung diseases.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWiener klinische Wochenschrift
Numberingvol. 135, no. 9-10, pp. 235-243
p-ISSN0043-5325
e-ISSN1613-7671
DOIhttps://doi.org/10.1007/s00508-023-02180-w
URN:NBNurn:nbn:hr:105:101032
Publication2023-05
Document URLhttps://link.springer.com/10.1007/s00508-023-02180-w
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-11-21 09:17:10