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Scientific paper - Review paper
EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders
Annals of the Rheumatic Diseases, 82 (2023), 7; 887-896. https://doi.org/10.1136/ard-2022-222852
Kuiper, Jonas JW; Prinz, Jörg C; Stratikos, Efstratios; Kuśnierczyk, Piotr; Arakawa, Akiko; Springer, Sebastian; Mintoff, Dillon; Padjen, Ivan; Shumnalieva, Russka; Vural, Seçil; Kötter, Ina; van de Sande, Marleen G; Boyvat, Ayşe; de Boer, Joke H; Bertsias, George; de Vries, Niek; Krieckaert, Charlotte LM; Leal, Inês; Vidovič Valentinčič, Nataša; Tugal-Tutkun, Ilknur; el Khaldi Ahanach, Hanane; Costantino, Félicie; Glatigny, Simon; Mrazovac Zimak, Danijela; Lötscher, Fabian; Kerstens, Floor G; Bakula, Marija; Viera Sousa, Elsa; Böhm, Peter; Bosman, Kees; Kenna, Tony J; Powis, Simon J; Breban, Maxime; Gul, Ahmet; Bowes, John; Lories, Rik JU; Nowatzky, Johannes; Wolbink, Gerrit Jan; McGonagle, Dennis G; Turkstra, Franktien More authors...

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Kuiper, J. J., Prinz, J. C., Stratikos, E., Kuśnierczyk, P., Arakawa, A., Springer, S. ... Turkstra, F. (2023). EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders. Annals of the Rheumatic Diseases, 82. (7), 887-896. doi: 10.1136/ard-2022-222852

Kuiper, Jonas JW, et al. "EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders." Annals of the Rheumatic Diseases, vol. 82, no. 7, 2023, pp. 887-896. https://doi.org/10.1136/ard-2022-222852

Kuiper, Jonas JW, Jörg C Prinz, Efstratios Stratikos, Piotr Kuśnierczyk, Akiko Arakawa, Sebastian Springer, Dillon Mintoff, et al. "EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders." Annals of the Rheumatic Diseases 82, no. 7 (2023): 887-896. https://doi.org/10.1136/ard-2022-222852

Kuiper, J. J., et al. (2023) 'EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders', Annals of the Rheumatic Diseases, 82(7), pp. 887-896. doi: 10.1136/ard-2022-222852

Kuiper JJ, Prinz JC, Stratikos E, Kuśnierczyk P, Arakawa A, Springer S, and sur.. EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders. Annals of the Rheumatic Diseases [Internet]. 2023 July [cited 2025 January 13];82(7):887-896. doi: 10.1136/ard-2022-222852

J. J. Kuiper, et al., "EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders", Annals of the Rheumatic Diseases, vol. 82, no. 7, pp. 887-896, July 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:090385. [Accessed: 13 January 2025]

Metadata
Title (english)EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders
AuthorJonas JW Kuiper
AuthorJörg C Prinz
AuthorEfstratios Stratikos
AuthorPiotr Kuśnierczyk
AuthorAkiko Arakawa
AuthorSebastian Springer
AuthorDillon Mintoff
AuthorIvan Padjen
AuthorRusska Shumnalieva
AuthorSeçil Vural
AuthorIna Kötter
AuthorMarleen G van de Sande
AuthorAyşe Boyvat
AuthorJoke H de Boer
AuthorGeorge Bertsias
AuthorNiek de Vries
AuthorCharlotte LM Krieckaert
AuthorInês Leal
AuthorNataša Vidovič Valentinčič
AuthorIlknur Tugal-Tutkun
AuthorHanane el Khaldi Ahanach
AuthorFélicie Costantino
AuthorSimon Glatigny
AuthorDanijela Mrazovac Zimak
AuthorFabian Lötscher
AuthorFloor G Kerstens
AuthorMarija Bakula
AuthorElsa Viera Sousa
AuthorPeter Böhm
AuthorKees Bosman
AuthorTony J Kenna
AuthorSimon J Powis
AuthorMaxime Breban
AuthorAhmet Gul
AuthorJohn Bowes
AuthorRik JU Lories
AuthorJohannes Nowatzky
AuthorGerrit Jan Wolbink
AuthorDennis G McGonagle
AuthorFranktien Turkstra
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The ‘MHC-I (major histocompatibility complex class I)-opathy’ concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet’s disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene variants of the antigen processing aminopeptidases ERAP1 and ERAP2 that implicates altered MHC-I peptide presentation to CD8+T cells in the pathogenesis. Progress in understanding the cause and treatment of these disorders is hampered by patient phenotypic heterogeneity and lack of systematic investigation of the MHC-I pathway. Here, we discuss new insights into the biology of MHC-I-opathies that strongly advocate for disease-overarching and integrated molecular and clinical investigation to decipher underlying disease mechanisms. Because this requires transformative multidisciplinary collaboration, we introduce the EULAR study group on MHC-I-opathies to unite clinical expertise in rheumatology, dermatology and ophthalmology, with fundamental and translational researchers from multiple disciplines such as immunology, genomics and proteomics, alongside patient partners. We prioritise standardisation of disease phenotypes and scientific nomenclature and propose interdisciplinary genetic and translational studies to exploit emerging therapeutic strategies to understand MHC-I-mediated disease mechanisms. These collaborative efforts are required to address outstanding questions in the etiopathogenesis of MHC-I-opathies towards improving patient treatment and prognostication.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAnnals of the Rheumatic Diseases
Numberingvol. 82, no. 7, pp. 887-896
p-ISSN0003-4967
e-ISSN1468-2060
DOIhttps://doi.org/10.1136/ard-2022-222852
URN:NBNurn:nbn:hr:105:090385
Publication2023-07
Document URLhttps://ard.bmj.com/lookup/doi/10.1136/ard-2022-222852
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2024-01-08 09:45:45