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EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders
Annals of the Rheumatic Diseases, 82 (2023), 7; 887-896. https://doi.org/10.1136/ard-2022-222852
Kuiper, Jonas JW; Prinz, Jörg C; Stratikos, Efstratios; Kuśnierczyk, Piotr; Arakawa, Akiko; Springer, Sebastian; Mintoff, Dillon; Padjen, Ivan; Shumnalieva, Russka; Vural, Seçil; Kötter, Ina; van de Sande, Marleen G; Boyvat, Ayşe; de Boer, Joke H; Bertsias, George; de Vries, Niek; Krieckaert, Charlotte LM; Leal, Inês; Vidovič Valentinčič, Nataša; Tugal-Tutkun, Ilknur; el Khaldi Ahanach, Hanane; Costantino, Félicie; Glatigny, Simon; Mrazovac Zimak, Danijela; Lötscher, Fabian; Kerstens, Floor G; Bakula, Marija; Viera Sousa, Elsa; Böhm, Peter; Bosman, Kees; Kenna, Tony J; Powis, Simon J; Breban, Maxime; Gul, Ahmet; Bowes, John; Lories, Rik JU; Nowatzky, Johannes; Wolbink, Gerrit Jan; McGonagle, Dennis G; Turkstra, Franktien Više autora...

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Kuiper, J. J., Prinz, J. C., Stratikos, E., Kuśnierczyk, P., Arakawa, A., Springer, S. ... Turkstra, F. (2023). EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders. Annals of the Rheumatic Diseases, 82. (7), 887-896. doi: 10.1136/ard-2022-222852

Kuiper, Jonas JW, et al. "EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders." Annals of the Rheumatic Diseases, vol. 82, br. 7, 2023, str. 887-896. https://doi.org/10.1136/ard-2022-222852

Kuiper, Jonas JW, Jörg C Prinz, Efstratios Stratikos, Piotr Kuśnierczyk, Akiko Arakawa, Sebastian Springer, Dillon Mintoff, et al. "EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders." Annals of the Rheumatic Diseases 82, br. 7 (2023): 887-896. https://doi.org/10.1136/ard-2022-222852

Kuiper, J. J., et al. (2023) 'EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders', Annals of the Rheumatic Diseases, 82(7), str. 887-896. doi: 10.1136/ard-2022-222852

Kuiper JJ, Prinz JC, Stratikos E, Kuśnierczyk P, Arakawa A, Springer S, i sur.. EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders. Annals of the Rheumatic Diseases [Internet]. 07.2023. [pristupljeno 25.12.2024.];82(7):887-896. doi: 10.1136/ard-2022-222852

J. J. Kuiper, et al., "EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders", Annals of the Rheumatic Diseases, vol. 82, br. 7, str. 887-896, Srpanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:090385. [Citirano: 25.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:090385
Podaci o radu
Naslov (engleski)EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders
AutorJonas JW Kuiper
AutorJörg C Prinz
AutorEfstratios Stratikos
AutorPiotr Kuśnierczyk
AutorAkiko Arakawa
AutorSebastian Springer
AutorDillon Mintoff
AutorIvan Padjen
AutorRusska Shumnalieva
AutorSeçil Vural
AutorIna Kötter
AutorMarleen G van de Sande
AutorAyşe Boyvat
AutorJoke H de Boer
AutorGeorge Bertsias
AutorNiek de Vries
AutorCharlotte LM Krieckaert
AutorInês Leal
AutorNataša Vidovič Valentinčič
AutorIlknur Tugal-Tutkun
AutorHanane el Khaldi Ahanach
AutorFélicie Costantino
AutorSimon Glatigny
AutorDanijela Mrazovac Zimak
AutorFabian Lötscher
AutorFloor G Kerstens
AutorMarija Bakula
AutorElsa Viera Sousa
AutorPeter Böhm
AutorKees Bosman
AutorTony J Kenna
AutorSimon J Powis
AutorMaxime Breban
AutorAhmet Gul
AutorJohn Bowes
AutorRik JU Lories
AutorJohannes Nowatzky
AutorGerrit Jan Wolbink
AutorDennis G McGonagle
AutorFranktien Turkstra
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
The ‘MHC-I (major histocompatibility complex class I)-opathy’ concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet’s disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene variants of the antigen processing aminopeptidases ERAP1 and ERAP2 that implicates altered MHC-I peptide presentation to CD8+T cells in the pathogenesis. Progress in understanding the cause and treatment of these disorders is hampered by patient phenotypic heterogeneity and lack of systematic investigation of the MHC-I pathway. Here, we discuss new insights into the biology of MHC-I-opathies that strongly advocate for disease-overarching and integrated molecular and clinical investigation to decipher underlying disease mechanisms. Because this requires transformative multidisciplinary collaboration, we introduce the EULAR study group on MHC-I-opathies to unite clinical expertise in rheumatology, dermatology and ophthalmology, with fundamental and translational researchers from multiple disciplines such as immunology, genomics and proteomics, alongside patient partners. We prioritise standardisation of disease phenotypes and scientific nomenclature and propose interdisciplinary genetic and translational studies to exploit emerging therapeutic strategies to understand MHC-I-mediated disease mechanisms. These collaborative efforts are required to address outstanding questions in the etiopathogenesis of MHC-I-opathies towards improving patient treatment and prognostication.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAnnals of the Rheumatic Diseases
Brojčani podacivol. 82, br. 7, str. 887-896
p-ISSN0003-4967
e-ISSN1468-2060
DOIhttps://doi.org/10.1136/ard-2022-222852
URN:NBNurn:nbn:hr:105:090385
Datum objave publikacije2023-07
URL dokumentahttps://ard.bmj.com/lookup/doi/10.1136/ard-2022-222852
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2024-01-08 09:45:45