prikaz prve stranice dokumenta Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma
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Scientific paper - Original scientific paper
Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma
International Journal of Molecular Sciences, 24 (2023), 6; 5816. https://doi.org/10.3390/ijms24065816
Tarle, Marko; Raguž, Marina; Muller, Danko; Lukšić, Ivica

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Tarle, M., Raguž, M., Muller, D. & Lukšić, I. (2023). Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences, 24. (6). doi: 10.3390/ijms24065816

Tarle, Marko, et al. "Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma." International Journal of Molecular Sciences, vol. 24, no. 6, 2023. https://doi.org/10.3390/ijms24065816

Tarle, Marko, Marina Raguž, Danko Muller and Ivica Lukšić. "Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma." International Journal of Molecular Sciences 24, no. 6 (2023). https://doi.org/10.3390/ijms24065816

Tarle, M., et al. (2023) 'Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma', International Journal of Molecular Sciences, 24(6). doi: 10.3390/ijms24065816

Tarle M, Raguž M, Muller D, Lukšić I. Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences [Internet]. 2023 March 18 [cited 2024 April 28];24(6). doi: 10.3390/ijms24065816

M. Tarle, M. Raguž, D. Muller and I. Lukšić, "Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma", International Journal of Molecular Sciences, vol. 24, no. 6, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:495325. [Accessed: 28 April 2024]

Metadata
Title (english)Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma
AuthorMarko Tarle
AuthorMarina Raguž
AuthorDanko Muller
AuthorIvica Lukšić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Maxillofacial Surgery and Dentistry)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
The aim of this study was to determine, by immunohistochemical methods, the expression of nEGFR and markers of cell proliferation (Ki-67), cell cycle (mEGFR, p53, cyclin D1), and tumor stem cells (ABCG2) in 59 pathohistological samples of healthy oral mucosa, 50 oral premalignant changes (leukoplakia and erythroplakia), and 52 oral squamous cell carcinomas (OSCC). An increase in the expression of mEGFR and nEGFR was found with the development of the disease (p < 0.0001). In the group of patients with leukoplakia and erythroplakia, we found a positive correlation between nEGFR and Ki67, p53, cyclin D1, and mEGFR, whereas in the group of patients with OSCC, we found a positive correlation between nEGFR and Ki67, mEGFR (p < 0.05). Tumors without perineural (PNI) invasion had a higher expression of p53 protein than tumors with PNI (p = 0.02). Patients with OSCC and overexpression of nEGFR had shorter overall survival (p = 0.004). The results of this study suggest a potentially important independent role of nEGFR in oral carcinogenesis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 6, 5816
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24065816
URN:NBNurn:nbn:hr:105:495325
Publication2023-03-18
Document URLhttps://www.mdpi.com/1422-0067/24/6/5816
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-08 11:43:35