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Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma
International Journal of Molecular Sciences, 24 (2023), 6; 5816. https://doi.org/10.3390/ijms24065816
Tarle, Marko; Raguž, Marina; Muller, Danko; Lukšić, Ivica

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Tarle, M., Raguž, M., Muller, D. i Lukšić, I. (2023). Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences, 24. (6). doi: 10.3390/ijms24065816

Tarle, Marko, et al. "Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma." International Journal of Molecular Sciences, vol. 24, br. 6, 2023. https://doi.org/10.3390/ijms24065816

Tarle, Marko, Marina Raguž, Danko Muller i Ivica Lukšić. "Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma." International Journal of Molecular Sciences 24, br. 6 (2023). https://doi.org/10.3390/ijms24065816

Tarle, M., et al. (2023) 'Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma', International Journal of Molecular Sciences, 24(6). doi: 10.3390/ijms24065816

Tarle M, Raguž M, Muller D, Lukšić I. Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences [Internet]. 18.03.2023. [pristupljeno 29.04.2024.];24(6). doi: 10.3390/ijms24065816

M. Tarle, M. Raguž, D. Muller i I. Lukšić, "Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma", International Journal of Molecular Sciences, vol. 24, br. 6, Ožujak 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:495325. [Citirano: 29.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:495325
Podaci o radu
Naslov (engleski)Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma
AutorMarko Tarle
AutorMarina Raguž
AutorDanko Muller
AutorIvica Lukšić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MAKSILOFACIJALNU KIRURGIJU SA STOMATOLOGIJOM)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
The aim of this study was to determine, by immunohistochemical methods, the expression of nEGFR and markers of cell proliferation (Ki-67), cell cycle (mEGFR, p53, cyclin D1), and tumor stem cells (ABCG2) in 59 pathohistological samples of healthy oral mucosa, 50 oral premalignant changes (leukoplakia and erythroplakia), and 52 oral squamous cell carcinomas (OSCC). An increase in the expression of mEGFR and nEGFR was found with the development of the disease (p < 0.0001). In the group of patients with leukoplakia and erythroplakia, we found a positive correlation between nEGFR and Ki67, p53, cyclin D1, and mEGFR, whereas in the group of patients with OSCC, we found a positive correlation between nEGFR and Ki67, mEGFR (p < 0.05). Tumors without perineural (PNI) invasion had a higher expression of p53 protein than tumors with PNI (p = 0.02). Patients with OSCC and overexpression of nEGFR had shorter overall survival (p = 0.004). The results of this study suggest a potentially important independent role of nEGFR in oral carcinogenesis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 6, 5816
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24065816
URN:NBNurn:nbn:hr:105:495325
Datum objave publikacije2023-03-18
URL dokumentahttps://www.mdpi.com/1422-0067/24/6/5816
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-08 11:43:35