prikaz prve stranice dokumenta Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland
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Scientific paper - Original scientific paper
Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland
International Journal of Molecular Sciences, 24 (2023), 6; 5609. https://doi.org/10.3390/ijms24065609
Hat, Koraljka; Planinić, Ana; Ježek, Davor; Kaštelan, Snježana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Hat, K., Planinić, A., Ježek, D. & Kaštelan, S. (2023). Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland. International Journal of Molecular Sciences, 24. (6). doi: 10.3390/ijms24065609

Hat, Koraljka, et al. "Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland." International Journal of Molecular Sciences, vol. 24, no. 6, 2023. https://doi.org/10.3390/ijms24065609

Hat, Koraljka, Ana Planinić, Davor Ježek and Snježana Kaštelan. "Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland." International Journal of Molecular Sciences 24, no. 6 (2023). https://doi.org/10.3390/ijms24065609

Hat, K., et al. (2023) 'Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland', International Journal of Molecular Sciences, 24(6). doi: 10.3390/ijms24065609

Hat K, Planinić A, Ježek D, Kaštelan S. Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland. International Journal of Molecular Sciences [Internet]. 2023 March 15 [cited 2024 November 29];24(6). doi: 10.3390/ijms24065609

K. Hat, A. Planinić, D. Ježek and S. Kaštelan, "Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland", International Journal of Molecular Sciences, vol. 24, no. 6, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:517370. [Accessed: 29 November 2024]

Metadata
Title (english)Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland
AuthorKoraljka Hat
AuthorAna Planinić
AuthorDavor Ježek
AuthorSnježana Kaštelan
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract (english)
Lacrimal gland dysfunction causes dry eye disease (DED) due to decreased tear production. Aqueous-deficient DED is more prevalent in women, suggesting that sexual dimorphism of the human lacrimal gland could be a potential cause. Sex steroid hormones are a key factor in the development of sexual dimorphism. This study aimed to quantify estrogen receptor (ER) and androgen receptor (AR) expression in the human lacrimal gland and compare it between sexes. RNA was isolated from 35 human lacrimal gland tissue samples collected from 19 cornea donors. AR, ERα, and ERβ mRNA was identified in all samples, and their expression was quantified using qPCR. Immunohistochemical staining was performed on selected samples to evaluate protein expression of the receptors. ERα mRNA expression was significantly higher than the expression of AR and ERβ. No difference in sex steroid hormone (SSH) receptor mRNA expression was observed between sexes, and no correlation was observed with age. If ERα protein expression is found to be concordant with mRNA expression, it should be investigated further as a potential target for hormone therapy of DED. Further research is needed to elucidate the role of sex steroid hormone receptors in sex-related differences of lacrimal gland structure and disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 6, 5609
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24065609
URN:NBNurn:nbn:hr:105:517370
Publication2023-03-15
Document URLhttps://www.mdpi.com/1422-0067/24/6/5609
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-08 12:32:24