prikaz prve stranice dokumenta Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland
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Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland
International Journal of Molecular Sciences, 24 (2023), 6; 5609. https://doi.org/10.3390/ijms24065609
Hat, Koraljka; Planinić, Ana; Ježek, Davor; Kaštelan, Snježana

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Hat, K., Planinić, A., Ježek, D. i Kaštelan, S. (2023). Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland. International Journal of Molecular Sciences, 24. (6). doi: 10.3390/ijms24065609

Hat, Koraljka, et al. "Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland." International Journal of Molecular Sciences, vol. 24, br. 6, 2023. https://doi.org/10.3390/ijms24065609

Hat, Koraljka, Ana Planinić, Davor Ježek i Snježana Kaštelan. "Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland." International Journal of Molecular Sciences 24, br. 6 (2023). https://doi.org/10.3390/ijms24065609

Hat, K., et al. (2023) 'Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland', International Journal of Molecular Sciences, 24(6). doi: 10.3390/ijms24065609

Hat K, Planinić A, Ježek D, Kaštelan S. Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland. International Journal of Molecular Sciences [Internet]. 15.03.2023. [pristupljeno 25.11.2024.];24(6). doi: 10.3390/ijms24065609

K. Hat, A. Planinić, D. Ježek i S. Kaštelan, "Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland", International Journal of Molecular Sciences, vol. 24, br. 6, Ožujak 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:517370. [Citirano: 25.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:517370
Podaci o radu
Naslov (engleski)Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland
AutorKoraljka Hat
AutorAna Planinić
AutorDavor Ježek
AutorSnježana Kaštelan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA HISTOLOGIJU I EMBRIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Sažetak (engleski)
Lacrimal gland dysfunction causes dry eye disease (DED) due to decreased tear production. Aqueous-deficient DED is more prevalent in women, suggesting that sexual dimorphism of the human lacrimal gland could be a potential cause. Sex steroid hormones are a key factor in the development of sexual dimorphism. This study aimed to quantify estrogen receptor (ER) and androgen receptor (AR) expression in the human lacrimal gland and compare it between sexes. RNA was isolated from 35 human lacrimal gland tissue samples collected from 19 cornea donors. AR, ERα, and ERβ mRNA was identified in all samples, and their expression was quantified using qPCR. Immunohistochemical staining was performed on selected samples to evaluate protein expression of the receptors. ERα mRNA expression was significantly higher than the expression of AR and ERβ. No difference in sex steroid hormone (SSH) receptor mRNA expression was observed between sexes, and no correlation was observed with age. If ERα protein expression is found to be concordant with mRNA expression, it should be investigated further as a potential target for hormone therapy of DED. Further research is needed to elucidate the role of sex steroid hormone receptors in sex-related differences of lacrimal gland structure and disease.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 6, 5609
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24065609
URN:NBNurn:nbn:hr:105:517370
Datum objave publikacije2023-03-15
URL dokumentahttps://www.mdpi.com/1422-0067/24/6/5609
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-08 12:32:24