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Scientific paper - Original scientific paper
Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia
Biomolecules, 13 (2023), 3; 570. https://doi.org/10.3390/biom13030570
Nikolac Perković, Matea; Borovečki, Fran; Filipčić, Igor; Vuić, Barbara; Miloš, Tina; Nedić Erjavec, Gordana; Konjevod, Marcela; Tudor, Lucija; Mimica, Ninoslav; Uzun, Suzana; Kozumplik, Oliver; Švob Štrac, Dubravka; Pivac, Nela

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Nikolac Perković, M., Borovečki, F., Filipčić, I., Vuić, B., Miloš, T., Nedić Erjavec, G. ... Pivac, N. (2023). Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia. Biomolecules, 13. (3). doi: 10.3390/biom13030570

Nikolac Perković, Matea, et al. "Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia." Biomolecules, vol. 13, no. 3, 2023. https://doi.org/10.3390/biom13030570

Nikolac Perković, Matea, Fran Borovečki, Igor Filipčić, Barbara Vuić, Tina Miloš, Gordana Nedić Erjavec, Marcela Konjevod, et al. "Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia." Biomolecules 13, no. 3 (2023). https://doi.org/10.3390/biom13030570

Nikolac Perković, M., et al. (2023) 'Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia', Biomolecules, 13(3). doi: 10.3390/biom13030570

Nikolac Perković M, Borovečki F, Filipčić I, Vuić B, Miloš T, Nedić Erjavec G, and sur.. Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia. Biomolecules [Internet]. 2023 March 21 [cited 2024 November 25];13(3). doi: 10.3390/biom13030570

M. Nikolac Perković, et al., "Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia", Biomolecules, vol. 13, no. 3, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:294907. [Accessed: 25 November 2024]

Metadata
Title (english)Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia
AuthorMatea Nikolac Perković
AuthorFran Borovečki
AuthorIgor Filipčić
AuthorBarbara Vuić
AuthorTina Miloš
AuthorGordana Nedić Erjavec
AuthorMarcela Konjevod
AuthorLucija Tudor
AuthorNinoslav Mimica
AuthorSuzana Uzun
AuthorOliver Kozumplik
AuthorDubravka Švob Štrac
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
In the last decade, increasing evidence has emerged linking alterations in the brain-derived neurotrophic factor (BDNF) expression with the development of Alzheimer’s disease (AD). Because of the important role of BDNF in cognition and its association with AD pathogenesis, the aim of this study was to evaluate the potential difference in plasma BDNF concentrations between subjects with mild cognitive impairment (MCI; N = 209) and AD patients (N = 295) and to determine the possible association between BDNF plasma levels and the degree of cognitive decline in these individuals. The results showed a significantly higher (p < 0.001) concentration of plasma BDNF in subjects with AD (1.16; 0.13–21.34) compared with individuals with MCI (0.68; 0.02–19.14). The results of the present study additionally indicated a negative correlation between cognitive functions and BDNF plasma concentrations, suggesting higher BDNF levels in subjects with more pronounced cognitive decline. The correlation analysis revealed a significant negative correlation between BDNF plasma levels and both Mini-Mental State Examination (p < 0.001) and Clock Drawing test (p < 0.001) scores. In conclusion, the results of our study point towards elevated plasma BDNF levels in AD patients compared with MCI subjects, which may be due to the body’s attempt to counteract the early and middle stages of neurodegeneration.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 13, no. 3, 570
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13030570
URN:NBNurn:nbn:hr:105:294907
Publication2023-03-21
ProjectNumber: IP-2019-04-6100
Title (croatian): Terapijski potencijal neurosteroida i neurotrofina u demenciji
Title (english): Therapeutic potential of neurosteroids and neurotrophins in dementia
Acronym: TePoNeDe
Leader: Dubravka Švob Štrac
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.mdpi.com/2218-273X/13/3/570
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-09 08:19:47