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Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia
Biomolecules, 13 (2023), 3; 570. https://doi.org/10.3390/biom13030570
Nikolac Perković, Matea; Borovečki, Fran; Filipčić, Igor; Vuić, Barbara; Miloš, Tina; Nedić Erjavec, Gordana; Konjevod, Marcela; Tudor, Lucija; Mimica, Ninoslav; Uzun, Suzana; Kozumplik, Oliver; Švob Štrac, Dubravka; Pivac, Nela

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Nikolac Perković, M., Borovečki, F., Filipčić, I., Vuić, B., Miloš, T., Nedić Erjavec, G. ... Pivac, N. (2023). Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia. Biomolecules, 13. (3). doi: 10.3390/biom13030570

Nikolac Perković, Matea, et al. "Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia." Biomolecules, vol. 13, br. 3, 2023. https://doi.org/10.3390/biom13030570

Nikolac Perković, Matea, Fran Borovečki, Igor Filipčić, Barbara Vuić, Tina Miloš, Gordana Nedić Erjavec, Marcela Konjevod, et al. "Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia." Biomolecules 13, br. 3 (2023). https://doi.org/10.3390/biom13030570

Nikolac Perković, M., et al. (2023) 'Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia', Biomolecules, 13(3). doi: 10.3390/biom13030570

Nikolac Perković M, Borovečki F, Filipčić I, Vuić B, Miloš T, Nedić Erjavec G, i sur.. Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia. Biomolecules [Internet]. 21.03.2023. [pristupljeno 05.11.2024.];13(3). doi: 10.3390/biom13030570

M. Nikolac Perković, et al., "Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia", Biomolecules, vol. 13, br. 3, Ožujak 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:294907. [Citirano: 05.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:294907
Podaci o radu
Naslov (engleski)Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia
AutorMatea Nikolac Perković
AutorFran Borovečki
AutorIgor Filipčić
AutorBarbara Vuić
AutorTina Miloš
AutorGordana Nedić Erjavec
AutorMarcela Konjevod
AutorLucija Tudor
AutorNinoslav Mimica
AutorSuzana Uzun
AutorOliver Kozumplik
AutorDubravka Švob Štrac
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
In the last decade, increasing evidence has emerged linking alterations in the brain-derived neurotrophic factor (BDNF) expression with the development of Alzheimer’s disease (AD). Because of the important role of BDNF in cognition and its association with AD pathogenesis, the aim of this study was to evaluate the potential difference in plasma BDNF concentrations between subjects with mild cognitive impairment (MCI; N = 209) and AD patients (N = 295) and to determine the possible association between BDNF plasma levels and the degree of cognitive decline in these individuals. The results showed a significantly higher (p < 0.001) concentration of plasma BDNF in subjects with AD (1.16; 0.13–21.34) compared with individuals with MCI (0.68; 0.02–19.14). The results of the present study additionally indicated a negative correlation between cognitive functions and BDNF plasma concentrations, suggesting higher BDNF levels in subjects with more pronounced cognitive decline. The correlation analysis revealed a significant negative correlation between BDNF plasma levels and both Mini-Mental State Examination (p < 0.001) and Clock Drawing test (p < 0.001) scores. In conclusion, the results of our study point towards elevated plasma BDNF levels in AD patients compared with MCI subjects, which may be due to the body’s attempt to counteract the early and middle stages of neurodegeneration.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 13, br. 3, 570
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13030570
URN:NBNurn:nbn:hr:105:294907
Datum objave publikacije2023-03-21
ProjektŠifra: IP-2019-04-6100
Naziv (hrvatski): Terapijski potencijal neurosteroida i neurotrofina u demenciji
Naziv (engleski): Therapeutic potential of neurosteroids and neurotrophins in dementia
Kratica: TePoNeDe
Voditelj: Dubravka Švob Štrac
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/2218-273X/13/3/570
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-09 08:19:47