prikaz prve stranice dokumenta Increased carotid intima-media thickness is associated with higher odds of unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia: a nested case-control study
  Download
PDF 175.98 KB
Scientific paper - Original scientific paper
Increased carotid intima-media thickness is associated with higher odds of unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia: a nested case-control study
Croatian Medical Journal, 64 (2023), 5; 344-353. https://doi.org/10.3325/cmj.2023.64.344
Crnjaković, Miljenko; Deveđija, Sabina; Vukorepa, Gorana; Rutović, Stela; Sporiš, Davor; Trkulja, Vladimir

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Crnjaković, M., Deveđija, S., Vukorepa, G., Rutović, S., Sporiš, D. & Trkulja, V. (2023). Increased carotid intima-media thickness is associated with higher odds of unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia: a nested case-control study. Croatian Medical Journal, 64. (5), 344-353. doi: 10.3325/cmj.2023.64.344

Crnjaković, Miljenko, et al. "Increased carotid intima-media thickness is associated with higher odds of unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia: a nested case-control study." Croatian Medical Journal, vol. 64, no. 5, 2023, pp. 344-353. https://doi.org/10.3325/cmj.2023.64.344

Crnjaković, Miljenko, Sabina Deveđija, Gorana Vukorepa, Stela Rutović, Davor Sporiš and Vladimir Trkulja. "Increased carotid intima-media thickness is associated with higher odds of unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia: a nested case-control study." Croatian Medical Journal 64, no. 5 (2023): 344-353. https://doi.org/10.3325/cmj.2023.64.344

Crnjaković, M., et al. (2023) 'Increased carotid intima-media thickness is associated with higher odds of unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia: a nested case-control study', Croatian Medical Journal, 64(5), pp. 344-353. doi: 10.3325/cmj.2023.64.344

Crnjaković M, Deveđija S, Vukorepa G, Rutović S, Sporiš D, Trkulja V. Increased carotid intima-media thickness is associated with higher odds of unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia: a nested case-control study. Croatian Medical Journal [Internet]. 2023 October 31 [cited 2024 November 23];64(5):344-353. doi: 10.3325/cmj.2023.64.344

M. Crnjaković, S. Deveđija, G. Vukorepa, S. Rutović, D. Sporiš and V. Trkulja, "Increased carotid intima-media thickness is associated with higher odds of unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia: a nested case-control study", Croatian Medical Journal, vol. 64, no. 5, pp. 344-353, October 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:860728. [Accessed: 23 November 2024]

Metadata
Title (english)Increased carotid intima-media thickness is associated with higher odds of unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia: a nested case-control study
AuthorMiljenko Crnjaković
AuthorSabina Deveđija
AuthorGorana Vukorepa
AuthorStela Rutović
AuthorDavor Sporiš
AuthorVladimir Trkulja
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Aim: To evaluate the association between carotid intima-media thickness (CIMT) at hospital admission and unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia to assess the feasibility of evaluating CIMT as a risk stratification aid in this setting. Methods: This proof-of-concept nested case-control study enrolled consecutive non-vaccinated adults free of advanced vascular diseases presenting with verified non-severe COVID-19 pneumonia between December 2020 and June 2021. CIMT was measured at admission, and patients were managed in line with the national Ministry of Health guidelines. Those who died or required mechanical ventilation (MV) during the index hospital stay were considered cases and were matched (entropy balancing, exact matching) on a set of covariates to survivors not requiring MV (controls). Frequentist and Bayesian logistic models were fitted to the case status. Results: The study enrolled 207 patients: 27 (13%) cases and 180 controls. All were retained in the analysis after entropy balancing, while 27 cases were exactly matched to 99 controls. Higher CIMT at the proximal internal carotid artery (both left and right) was consistently associated with higher odds of being a case: all odds ratio point-estimates were ≥1.50 with lower limits of the 99% confidence intervals/credibility intervals ≥1.00 with two-sided probabilities of OR>1.00 greater than 99.5%. The susceptibility of the estimates to unmeasured confounding was low. Conclusion: This study supports the feasibility of CIMT as a risk stratification aid in adults free of advanced vascular disease presenting with non-severe COVID-19 pneumonia.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 64, no. 5, pp. 344-353
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2023.64.344
URN:NBNurn:nbn:hr:105:860728
Publication2023-10-31
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668038/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-01-09 13:11:31