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Scientific paper - Review paper
Diagnostic and Management Strategies of IgA Vasculitis Nephritis/Henoch-Schönlein Purpura Nephritis in Pediatric Patients: Current Perspectives
Pediatric Health, Medicine and Therapeutics, 14 (2023); 89-98. https://doi.org/10.2147/PHMT.S379862
Šestan, Mario; Jelušić, Marija

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Šestan, M. & Jelušić, M. (2023). Diagnostic and Management Strategies of IgA Vasculitis Nephritis/Henoch-Schönlein Purpura Nephritis in Pediatric Patients: Current Perspectives. Pediatric Health, Medicine and Therapeutics, 14., 89-98. doi: 10.2147/PHMT.S379862

Šestan, Mario and Marija Jelušić. "Diagnostic and Management Strategies of IgA Vasculitis Nephritis/Henoch-Schönlein Purpura Nephritis in Pediatric Patients: Current Perspectives." Pediatric Health, Medicine and Therapeutics, vol. 14, 2023, pp. 89-98. https://doi.org/10.2147/PHMT.S379862

Šestan, Mario and Marija Jelušić. "Diagnostic and Management Strategies of IgA Vasculitis Nephritis/Henoch-Schönlein Purpura Nephritis in Pediatric Patients: Current Perspectives." Pediatric Health, Medicine and Therapeutics 14 (2023): 89-98. https://doi.org/10.2147/PHMT.S379862

Šestan, M. and Jelušić, M. (2023) 'Diagnostic and Management Strategies of IgA Vasculitis Nephritis/Henoch-Schönlein Purpura Nephritis in Pediatric Patients: Current Perspectives', Pediatric Health, Medicine and Therapeutics, 14, pp. 89-98. doi: 10.2147/PHMT.S379862

Šestan M, Jelušić M. Diagnostic and Management Strategies of IgA Vasculitis Nephritis/Henoch-Schönlein Purpura Nephritis in Pediatric Patients: Current Perspectives. Pediatric Health, Medicine and Therapeutics [Internet]. 2023 March 07 [cited 2025 January 14];14:89-98. doi: 10.2147/PHMT.S379862

M. Šestan and M. Jelušić, "Diagnostic and Management Strategies of IgA Vasculitis Nephritis/Henoch-Schönlein Purpura Nephritis in Pediatric Patients: Current Perspectives", Pediatric Health, Medicine and Therapeutics, vol. 14, pp. 89-98, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:542113. [Accessed: 14 January 2025]

Metadata
Title (english)Diagnostic and Management Strategies of IgA Vasculitis Nephritis/Henoch-Schönlein Purpura Nephritis in Pediatric Patients: Current Perspectives
AuthorMario Šestan
AuthorMarija Jelušić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract (english)
IgA vasculitis (IgAV) or Henoch-Schönlein purpura (HSP) is the most common vasculitis in children, and nephritis (IgAVN or HSPN) is the most important and only chronic manifestation of the disease. Despite this, there are no diagnostic criteria and we rely on the European League Against Rheumatism/Paediatric Rheumatology International Trials Organization/Paediatric Rheumatology European Society-endorsed Ankara 2008 classification criteria in our daily practice. Basic investigations that should be done in every patient with IgAVN include blood pressure measurement, estimated glomerular filtration rate and urinalysis. Kidney biopsy is still the gold standard for the diagnosis of IgAVN since noninvasive confirmation of nephritis is still pending. According to the Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) recommendations, the first-line treatment for with mild forms of IgAVN is oral glucocorticoids, for patients with moderate IgAVN parenterally administrated glucocorticoids in pulsed doses, while initial treatment for patients with the most severe forms of IgAVN include pulsed doses of glucocorticoids in combination with intravenous cyclophosphamide pulses. New therapeutic options are currently being tested, aiming to reduce the production of galactose-deficient IgA1 and autoantibodies or suppress the alternative or lectin complement pathway and blocking mesangial cell activation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePediatric Health, Medicine and Therapeutics
Numberingvol. 14, pp. 89-98
e-ISSN1179-9927
DOIhttps://doi.org/10.2147/PHMT.S379862
URN:NBNurn:nbn:hr:105:542113
Publication2023-03-07
Document URLhttps://www.dovepress.com/diagnostic-and-management-strategies-of-iga-vasculitis-nephritishenoch-peer-reviewed-fulltext-article-PHMT
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) icon
Created on2024-01-11 10:12:38