prikaz prve stranice dokumenta Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
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Scientific paper - Original scientific paper
Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
Brain Structure and Function, 228 (2023), 2; 613-633. https://doi.org/10.1007/s00429-022-02606-7
Junaković, Alisa; Kopić, Janja; Duque, Alvaro; Rakic, Pasko; Krsnik, Željka; Kostović, Ivica

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Junaković, A., Kopić, J., Duque, A., Rakic, P., Krsnik, Ž. & Kostović, I. (2023). Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization. Brain Structure and Function, 228. (2), 613-633. doi: 10.1007/s00429-022-02606-7

Junaković, Alisa, et al. "Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization." Brain Structure and Function, vol. 228, no. 2, 2023, pp. 613-633. https://doi.org/10.1007/s00429-022-02606-7

Junaković, Alisa, Janja Kopić, Alvaro Duque, Pasko Rakic, Željka Krsnik and Ivica Kostović. "Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization." Brain Structure and Function 228, no. 2 (2023): 613-633. https://doi.org/10.1007/s00429-022-02606-7

Junaković, A., et al. (2023) 'Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization', Brain Structure and Function, 228(2), pp. 613-633. doi: 10.1007/s00429-022-02606-7

Junaković A, Kopić J, Duque A, Rakic P, Krsnik Ž, Kostović I. Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization. Brain Structure and Function [Internet]. 2023 March 02 [cited 2024 November 23];228(2):613-633. doi: 10.1007/s00429-022-02606-7

A. Junaković, J. Kopić, A. Duque, P. Rakic, Ž. Krsnik and I. Kostović, "Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization", Brain Structure and Function, vol. 228, no. 2, pp. 613-633, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:526033. [Accessed: 23 November 2024]

Metadata
Title (english)Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
AuthorAlisa Junaković
AuthorJanja Kopić
AuthorAlvaro Duque
AuthorPasko Rakic
AuthorŽeljka Krsnik
AuthorIvica Kostović
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
The cingulate gyrus, as a prominent part of the human limbic lobe, is involved in the integration and regulation of complex emotional, executive, motivational, and cognitive functions, attributed to several functional regions along the anteroposterior axis. In contrast to increasing knowledge of cingulate function in the adult brain, our knowledge of cingulate development is based primarily on classical neuroembryological studies. We aimed to reveal the laminar and cellular development of the various cingulate regions during the critical period from 7.5 to 15 postconceptional weeks (PCW) before the formation of Brodmann type arealization, employing diverse molecular markers on serial histological sections of postmortem human fetal brains. The study was performed by analysis of: (1) deep projection neuron (DPN) markers laminar dynamics, (2) all transient laminar compartments, and (3) characteristic subplate (SP) formation-expansion phase. We found that DPN markers labeling an incipient cortical plate (CP) were the first sign of regional differentiation of the dorsal isocortical and ventral mesocortical belt. Remarkably, increased width of the fibrillar marginal zone (MZ) towards the limbus, in parallel with the narrowing of CP containing DPN, as well as the diminishment of subventricular zone (SVZ) were reliable landmarks of early mesocortical differentiation. Finally, the SP formation pattern was shown to be a crucial event in the isocortical cingulate portion, given that the mesocortical belt is characterized by an incomplete CP delamination and absence of SP expansion. In conclusion, laminar DPN markers dynamics, together with the SVZ size and mode of SP formation indicate regional belt-like cingulate cortex differentiation before the corpus callosum expansion and several months before Brodmann type arealization.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBrain Structure and Function
Numberingvol. 228, no. 2, pp. 613-633
e-ISSN1863-2661
DOIhttps://doi.org/10.1007/s00429-022-02606-7
URN:NBNurn:nbn:hr:105:526033
Publication2023-03-02
Document URLhttps://link.springer.com/10.1007/s00429-022-02606-7
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-02-29 11:12:19