prikaz prve stranice dokumenta Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
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Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
Brain Structure and Function, 228 (2023), 2; 613-633. https://doi.org/10.1007/s00429-022-02606-7
Junaković, Alisa; Kopić, Janja; Duque, Alvaro; Rakic, Pasko; Krsnik, Željka; Kostović, Ivica

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Junaković, A., Kopić, J., Duque, A., Rakic, P., Krsnik, Ž. i Kostović, I. (2023). Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization. Brain Structure and Function, 228. (2), 613-633. doi: 10.1007/s00429-022-02606-7

Junaković, Alisa, et al. "Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization." Brain Structure and Function, vol. 228, br. 2, 2023, str. 613-633. https://doi.org/10.1007/s00429-022-02606-7

Junaković, Alisa, Janja Kopić, Alvaro Duque, Pasko Rakic, Željka Krsnik i Ivica Kostović. "Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization." Brain Structure and Function 228, br. 2 (2023): 613-633. https://doi.org/10.1007/s00429-022-02606-7

Junaković, A., et al. (2023) 'Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization', Brain Structure and Function, 228(2), str. 613-633. doi: 10.1007/s00429-022-02606-7

Junaković A, Kopić J, Duque A, Rakic P, Krsnik Ž, Kostović I. Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization. Brain Structure and Function [Internet]. 02.03.2023. [pristupljeno 29.04.2024.];228(2):613-633. doi: 10.1007/s00429-022-02606-7

A. Junaković, J. Kopić, A. Duque, P. Rakic, Ž. Krsnik i I. Kostović, "Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization", Brain Structure and Function, vol. 228, br. 2, str. 613-633, Ožujak 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:526033. [Citirano: 29.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:526033
Podaci o radu
Naslov (engleski)Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
AutorAlisa Junaković
AutorJanja Kopić
AutorAlvaro Duque
AutorPasko Rakic
AutorŽeljka Krsnik
AutorIvica Kostović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
The cingulate gyrus, as a prominent part of the human limbic lobe, is involved in the integration and regulation of complex emotional, executive, motivational, and cognitive functions, attributed to several functional regions along the anteroposterior axis. In contrast to increasing knowledge of cingulate function in the adult brain, our knowledge of cingulate development is based primarily on classical neuroembryological studies. We aimed to reveal the laminar and cellular development of the various cingulate regions during the critical period from 7.5 to 15 postconceptional weeks (PCW) before the formation of Brodmann type arealization, employing diverse molecular markers on serial histological sections of postmortem human fetal brains. The study was performed by analysis of: (1) deep projection neuron (DPN) markers laminar dynamics, (2) all transient laminar compartments, and (3) characteristic subplate (SP) formation-expansion phase. We found that DPN markers labeling an incipient cortical plate (CP) were the first sign of regional differentiation of the dorsal isocortical and ventral mesocortical belt. Remarkably, increased width of the fibrillar marginal zone (MZ) towards the limbus, in parallel with the narrowing of CP containing DPN, as well as the diminishment of subventricular zone (SVZ) were reliable landmarks of early mesocortical differentiation. Finally, the SP formation pattern was shown to be a crucial event in the isocortical cingulate portion, given that the mesocortical belt is characterized by an incomplete CP delamination and absence of SP expansion. In conclusion, laminar DPN markers dynamics, together with the SVZ size and mode of SP formation indicate regional belt-like cingulate cortex differentiation before the corpus callosum expansion and several months before Brodmann type arealization.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBrain Structure and Function
Brojčani podacivol. 228, br. 2, str. 613-633
e-ISSN1863-2661
DOIhttps://doi.org/10.1007/s00429-022-02606-7
URN:NBNurn:nbn:hr:105:526033
Datum objave publikacije2023-03-02
URL dokumentahttps://link.springer.com/10.1007/s00429-022-02606-7
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-02-29 11:12:19