prikaz prve stranice dokumenta Strategy for mapping quantitative trait loci (QTL) by using human metapopulations
  Download
PDF 816.38 KB
Scientific paper - Original scientific paper
Strategy for mapping quantitative trait loci (QTL) by using human metapopulations
Croatian Medical Journal, 47 (2006), 4; 532-542. urn:nbn:hr:105:124063
Rudan, Igor; Biloglav, Zrinka; Carothers, Andrew D.; Wright, Alan F.; Campbell, Harry

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Rudan, I., Biloglav, Z., Carothers, A. D., Wright, A. F. & Campbell, H. (2006). Strategy for mapping quantitative trait loci (QTL) by using human metapopulations. Croatian Medical Journal, 47. (4), 532-542. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:124063

Rudan, Igor, et al. "Strategy for mapping quantitative trait loci (QTL) by using human metapopulations." Croatian Medical Journal, vol. 47, no. 4, 2006, pp. 532-542. https://urn.nsk.hr/urn:nbn:hr:105:124063

Rudan, Igor, Zrinka Biloglav, Andrew D. Carothers, Alan F. Wright and Harry Campbell. "Strategy for mapping quantitative trait loci (QTL) by using human metapopulations." Croatian Medical Journal 47, no. 4 (2006): 532-542. https://urn.nsk.hr/urn:nbn:hr:105:124063

Rudan, I., et al. (2006) 'Strategy for mapping quantitative trait loci (QTL) by using human metapopulations', Croatian Medical Journal, 47(4), pp. 532-542. Available at: https://urn.nsk.hr/urn:nbn:hr:105:124063 (Accessed 16 May 2024)

Rudan I, Biloglav Z, Carothers AD, Wright AF, Campbell H. Strategy for mapping quantitative trait loci (QTL) by using human metapopulations. Croatian Medical Journal [Internet]. 2006 August [cited 2024 May 16];47(4):532-542. Available at: https://urn.nsk.hr/urn:nbn:hr:105:124063

I. Rudan, Z. Biloglav, A. D. Carothers, A. F. Wright and H. Campbell, "Strategy for mapping quantitative trait loci (QTL) by using human metapopulations", Croatian Medical Journal, vol. 47, no. 4, pp. 532-542, August 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:124063. [Accessed: 16 May 2024]

Metadata
Title (english)Strategy for mapping quantitative trait loci (QTL) by using human metapopulations
AuthorIgor Rudan
AuthorZrinka Biloglav
AuthorAndrew D. Carothers
AuthorAlan F. Wright
AuthorHarry Campbell
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Abstract (english)
Aim. To present a novel strategy for mapping quantitative trait loci (QTL), using human metapopulations. The strategy is based on the expectation that in geographic clusters of small and distinct human isolates, a combination of founder effect and genetic drift can dramatically increase population frequency of rare QTL variants with large effect. In such cases, the distribution of QT measurements in an “affected” isolate is expected to deviate from that observed in neighboring isolates. - - - - - Methods. We tested this hypothesis in 9 villages from a larger Croatian isolate resource, where 7 Mendelian disorders have been previously reported. The values of 10 physiological and biochemical QTs were measured in a random sample of 1001 individuals (100 inhabitants of each of 9 villages and 101 immigrant controls). - - - - - Results. Significant over- or under- representation of individuals from specific villages in extreme ends of standardized QT measurement distribution was found 10 times more frequently than expected by chance. The large majority of such clusters of individuals with extreme QT values (34/36, 94.4%) originated from the 6 villages with the most pronounced geographic isolation and endogamy. - - - - - Conclusion. Early epidemiological assessment supports the feasibility of the proposed strategy. Clusters of individuals with extreme QT values responsible for over-representation of single villages can usually be linked to a larger pedigree and may be useful for further QTL mapping, using linkage analysis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 47, no. 4, pp. 532-542
p-ISSN0353-9504
URN:NBNurn:nbn:hr:105:124063
Publication2006-08
Document URLhttp://www.cmj.hr/2006/47/4/16909450.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:01:35