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Strategy for mapping quantitative trait loci (QTL) by using human metapopulations
Croatian Medical Journal, 47 (2006), 4; 532-542. urn:nbn:hr:105:124063
Rudan, Igor; Biloglav, Zrinka; Carothers, Andrew D.; Wright, Alan F.; Campbell, Harry

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Rudan, I., Biloglav, Z., Carothers, A. D., Wright, A. F. i Campbell, H. (2006). Strategy for mapping quantitative trait loci (QTL) by using human metapopulations. Croatian Medical Journal, 47. (4), 532-542. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:124063

Rudan, Igor, et al. "Strategy for mapping quantitative trait loci (QTL) by using human metapopulations." Croatian Medical Journal, vol. 47, br. 4, 2006, str. 532-542. https://urn.nsk.hr/urn:nbn:hr:105:124063

Rudan, Igor, Zrinka Biloglav, Andrew D. Carothers, Alan F. Wright i Harry Campbell. "Strategy for mapping quantitative trait loci (QTL) by using human metapopulations." Croatian Medical Journal 47, br. 4 (2006): 532-542. https://urn.nsk.hr/urn:nbn:hr:105:124063

Rudan, I., et al. (2006) 'Strategy for mapping quantitative trait loci (QTL) by using human metapopulations', Croatian Medical Journal, 47(4), str. 532-542. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:124063 (Datum pristupa: 18.11.2024.)

Rudan I, Biloglav Z, Carothers AD, Wright AF, Campbell H. Strategy for mapping quantitative trait loci (QTL) by using human metapopulations. Croatian Medical Journal [Internet]. 08.2006. [pristupljeno 18.11.2024.];47(4):532-542. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:124063

I. Rudan, Z. Biloglav, A. D. Carothers, A. F. Wright i H. Campbell, "Strategy for mapping quantitative trait loci (QTL) by using human metapopulations", Croatian Medical Journal, vol. 47, br. 4, str. 532-542, Kolovoz 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:124063. [Citirano: 18.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:124063
Podaci o radu
Naslov (engleski)Strategy for mapping quantitative trait loci (QTL) by using human metapopulations
AutorIgor Rudan
AutorZrinka Biloglav
AutorAndrew D. Carothers
AutorAlan F. Wright
AutorHarry Campbell
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Sažetak (engleski)
Aim. To present a novel strategy for mapping quantitative trait loci (QTL), using human metapopulations. The strategy is based on the expectation that in geographic clusters of small and distinct human isolates, a combination of founder effect and genetic drift can dramatically increase population frequency of rare QTL variants with large effect. In such cases, the distribution of QT measurements in an “affected” isolate is expected to deviate from that observed in neighboring isolates. - - - - - Methods. We tested this hypothesis in 9 villages from a larger Croatian isolate resource, where 7 Mendelian disorders have been previously reported. The values of 10 physiological and biochemical QTs were measured in a random sample of 1001 individuals (100 inhabitants of each of 9 villages and 101 immigrant controls). - - - - - Results. Significant over- or under- representation of individuals from specific villages in extreme ends of standardized QT measurement distribution was found 10 times more frequently than expected by chance. The large majority of such clusters of individuals with extreme QT values (34/36, 94.4%) originated from the 6 villages with the most pronounced geographic isolation and endogamy. - - - - - Conclusion. Early epidemiological assessment supports the feasibility of the proposed strategy. Clusters of individuals with extreme QT values responsible for over-representation of single villages can usually be linked to a larger pedigree and may be useful for further QTL mapping, using linkage analysis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 47, br. 4, str. 532-542
p-ISSN0353-9504
URN:NBNurn:nbn:hr:105:124063
Datum objave publikacije2006-08
URL dokumentahttp://www.cmj.hr/2006/47/4/16909450.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:01:35