prikaz prve stranice dokumenta Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents
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Scientific paper - Original scientific paper
Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 36 (2012), 1; 136-140. https://doi.org/10.1016/j.pnpbp.2011.08.003
Škledar, Marijana; Nikolac, Matea; Dodig-Ćurković, Katarina; Ćurković, Mario; Borovečki, Fran; Pivac, Nela

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Škledar, M., Nikolac, M., Dodig Ćurković, K., Ćurković, M., Borovečki, F. & Pivac, N. (2012). Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 36. (1), 136-140. doi: 10.1016/j.pnpbp.2011.08.003

Škledar, Marijana, et al. "Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents." Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 36, no. 1, 2012, pp. 136-140. https://doi.org/10.1016/j.pnpbp.2011.08.003

Škledar, Marijana, Matea Nikolac, Katarina Dodig Ćurković, Mario Ćurković, Fran Borovečki and Nela Pivac. "Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents." Progress in Neuro-Psychopharmacology and Biological Psychiatry 36, no. 1 (2012): 136-140. https://doi.org/10.1016/j.pnpbp.2011.08.003

Škledar, M., et al. (2012) 'Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 36(1), pp. 136-140. doi: 10.1016/j.pnpbp.2011.08.003

Škledar M, Nikolac M, Dodig Ćurković K, Ćurković M, Borovečki F, Pivac N. Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents. Progress in Neuro-Psychopharmacology and Biological Psychiatry [Internet]. 2012 January 10 [cited 2024 April 28];36(1):136-140. doi: 10.1016/j.pnpbp.2011.08.003

M. Škledar, M. Nikolac, K. Dodig Ćurković, M. Ćurković, F. Borovečki and N. Pivac, "Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents", Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 36, no. 1, pp. 136-140, January 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:515700. [Accessed: 28 April 2024]

Metadata
Title (english)Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents
AuthorMarijana Škledar
AuthorMatea Nikolac
AuthorKatarina Dodig-Ćurković
AuthorMario Ćurković
AuthorFran Borovečki
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Obesity in children and adolescents is a worldwide health problem, characterized by various somatic, psychosocial and psychiatric complications, and is often associated with adult obesity and related complications. Brain-derived neurotrophic factor (BDNF) is a neurotrophin with important roles in feeding behavior, food intake regulation, energy metabolism and weight control. A common polymorphism of the BDNF genotype (Val66Met) has been associated with various forms of eating disorders, alterations in body mass index (BMI) values and obesity in adult populations. The aim of this study was to determine the association between the gene variants of the BDNF Val66Met polymorphism and obesity in 300 healthy Caucasian children and adolescents of the same ethnic background of Croatian origin, subdivided according to the BMI percentile, but without any form of eating disorders. The frequency of the Met/Met, Met/Val and Val/Val genotypes, Met and Val alleles, and Met carriers (the combined Met/Met and Met/Val genotypes versus the homozygous Val/Val genotype) differed significantly between underweight, normal weight, overweight and obese children, and the presence of one or two Met alleles contributed to this significant effect. These results showed for the first time the significant association between the presence of one or two Met alleles and obesity in ethnically homogenous groups of healthy Caucasian children and adolescents. These data confirmed the major role of BDNF in energy metabolism, food regulation and BMI.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleProgress in Neuro-Psychopharmacology and Biological Psychiatry
Numberingvol. 36, no. 1, pp. 136-140
p-ISSN0278-5846
DOIhttps://doi.org/10.1016/j.pnpbp.2011.08.003
URN:NBNurn:nbn:hr:105:515700
Publication2012-01-10
Document URLhttps://doi.org/10.1016/j.pnpbp.2011.08.003
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:11:26