prikaz prve stranice dokumenta Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents
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Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 36 (2012), 1; 136-140. https://doi.org/10.1016/j.pnpbp.2011.08.003
Škledar, Marijana; Nikolac, Matea; Dodig-Ćurković, Katarina; Ćurković, Mario; Borovečki, Fran; Pivac, Nela

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Škledar, M., Nikolac, M., Dodig Ćurković, K., Ćurković, M., Borovečki, F. i Pivac, N. (2012). Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 36. (1), 136-140. doi: 10.1016/j.pnpbp.2011.08.003

Škledar, Marijana, et al. "Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents." Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 36, br. 1, 2012, str. 136-140. https://doi.org/10.1016/j.pnpbp.2011.08.003

Škledar, Marijana, Matea Nikolac, Katarina Dodig Ćurković, Mario Ćurković, Fran Borovečki i Nela Pivac. "Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents." Progress in Neuro-Psychopharmacology and Biological Psychiatry 36, br. 1 (2012): 136-140. https://doi.org/10.1016/j.pnpbp.2011.08.003

Škledar, M., et al. (2012) 'Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 36(1), str. 136-140. doi: 10.1016/j.pnpbp.2011.08.003

Škledar M, Nikolac M, Dodig Ćurković K, Ćurković M, Borovečki F, Pivac N. Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents. Progress in Neuro-Psychopharmacology and Biological Psychiatry [Internet]. 10.01.2012. [pristupljeno 28.04.2024.];36(1):136-140. doi: 10.1016/j.pnpbp.2011.08.003

M. Škledar, M. Nikolac, K. Dodig Ćurković, M. Ćurković, F. Borovečki i N. Pivac, "Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents", Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 36, br. 1, str. 136-140, Siječanj 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:515700. [Citirano: 28.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:515700
Podaci o radu
Naslov (engleski)Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents
AutorMarijana Škledar
AutorMatea Nikolac
AutorKatarina Dodig-Ćurković
AutorMario Ćurković
AutorFran Borovečki
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Obesity in children and adolescents is a worldwide health problem, characterized by various somatic, psychosocial and psychiatric complications, and is often associated with adult obesity and related complications. Brain-derived neurotrophic factor (BDNF) is a neurotrophin with important roles in feeding behavior, food intake regulation, energy metabolism and weight control. A common polymorphism of the BDNF genotype (Val66Met) has been associated with various forms of eating disorders, alterations in body mass index (BMI) values and obesity in adult populations. The aim of this study was to determine the association between the gene variants of the BDNF Val66Met polymorphism and obesity in 300 healthy Caucasian children and adolescents of the same ethnic background of Croatian origin, subdivided according to the BMI percentile, but without any form of eating disorders. The frequency of the Met/Met, Met/Val and Val/Val genotypes, Met and Val alleles, and Met carriers (the combined Met/Met and Met/Val genotypes versus the homozygous Val/Val genotype) differed significantly between underweight, normal weight, overweight and obese children, and the presence of one or two Met alleles contributed to this significant effect. These results showed for the first time the significant association between the presence of one or two Met alleles and obesity in ethnically homogenous groups of healthy Caucasian children and adolescents. These data confirmed the major role of BDNF in energy metabolism, food regulation and BMI.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaProgress in Neuro-Psychopharmacology and Biological Psychiatry
Brojčani podacivol. 36, br. 1, str. 136-140
p-ISSN0278-5846
DOIhttps://doi.org/10.1016/j.pnpbp.2011.08.003
URN:NBNurn:nbn:hr:105:515700
Datum objave publikacije2012-01-10
URL dokumentahttps://doi.org/10.1016/j.pnpbp.2011.08.003
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:11:26