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Scientific paper - Original scientific paper
Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study
Croatian Medical Journal, 52 (2011), 2; 171-177. https://doi.org/10.3325/cmj.2011.52.171
Matković, Božica; Juretić, Antonio; Spagnoli, Giulio C.; Šeparović, Viktor; Gamulin, Marija; Šeparović, Robert; Šarić, Nera; Bašić-Koretić, Martina; Novosel, Irena; Krušlin, Božo

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Matković, B., Juretić, A., Spagnoli, G. C., Šeparović, V., Gamulin, M., Šeparović, R. ... Krušlin, B. (2011). Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study. Croatian Medical Journal, 52. (2), 171-177. doi: 10.3325/cmj.2011.52.171

Matković, Božica, et al. "Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study." Croatian Medical Journal, vol. 52, no. 2, 2011, pp. 171-177. https://doi.org/10.3325/cmj.2011.52.171

Matković, Božica, Antonio Juretić, Giulio C. Spagnoli, Viktor Šeparović, Marija Gamulin, Robert Šeparović, Nera Šarić, Martina Bašić Koretić, Irena Novosel and Božo Krušlin. "Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study." Croatian Medical Journal 52, no. 2 (2011): 171-177. https://doi.org/10.3325/cmj.2011.52.171

Matković, B., et al. (2011) 'Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study', Croatian Medical Journal, 52(2), pp. 171-177. doi: 10.3325/cmj.2011.52.171

Matković B, Juretić A, Spagnoli GC, Šeparović V, Gamulin M, Šeparović R, and sur.. Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study. Croatian Medical Journal [Internet]. 2011 April 15 [cited 2024 December 27];52(2):171-177. doi: 10.3325/cmj.2011.52.171

B. Matković, et al., "Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study", Croatian Medical Journal, vol. 52, no. 2, pp. 171-177, April 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:222059. [Accessed: 27 December 2024]

Metadata
Title (english)Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study
AuthorBožica Matković
AuthorAntonio Juretić
AuthorGiulio C. Spagnoli
AuthorViktor Šeparović
AuthorMarija Gamulin
AuthorRobert Šeparović
AuthorNera Šarić
AuthorMartina Bašić-Koretić
AuthorIrena Novosel
AuthorBožo Krušlin
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To immunohistochemically evaluate the expression of MAGE-A1, MAGE-A, and NY-ESO-1 cancer/testis (C/T) tumor antigens in medullary breast cancer (MBC) tumor samples and to analyze it in relation to the clinicopathological features. ----- METHODS: This retrospective study included samples from 49 patients: 40 with typical MBC and 9 with atypical MBC. Tumor specimens were obtained from patients operated on in the University Hospital for Tumors and the Sisters of Mercy University Hospital, Zagreb, Croatia, from 1999 to 2005. Standard immunohistochemistry was used on archival paraffin-embedded MBC tissues. ----- RESULTS: MAGE-A1, MAGE-A, and NY-ESO-1 antigens were expressed in 33% (16/49), 33% (16/49), and 22% (11/49) of patients, respectively. No difference between the groups with and without C/T tumor antigen expression in age at diagnosis, tumor size, axillary lymph node metastasis, adjuvant therapy, and HER-2 expression was identified. Significantly more patients died in the MAGE-A-positive group than in the MAGE-A-negative group (P=0.010), whereas a borderline significance was found between MAGE-A1-positive and the MAGE-A1-negative group (P=0.079) and between NY-ESO-1-positive and NY-ESO-1-negative group (P=0.117). Overall survival, as evaluated by the Kaplan-Meier curves, was lower in MAGE-A1- (P=0.031), MAGE-A- (P=0.004), NY-ESO-1-positive groups (P=0.077). ----- CONCLUSION: Expression of C/T antigens may represent a marker of potential prognostic relevance in MBC.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 52, no. 2, pp. 171-177
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2011.52.171
URN:NBNurn:nbn:hr:105:222059
Publication2011-04-15
Document URLhttp://www.cmj.hr/2011/52/2/21495200.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:13:38