prikaz prve stranice dokumenta Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study
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Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study
Croatian Medical Journal, 52 (2011), 2; 171-177. https://doi.org/10.3325/cmj.2011.52.171
Matković, Božica; Juretić, Antonio; Spagnoli, Giulio C.; Šeparović, Viktor; Gamulin, Marija; Šeparović, Robert; Šarić, Nera; Bašić-Koretić, Martina; Novosel, Irena; Krušlin, Božo

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Matković, B., Juretić, A., Spagnoli, G. C., Šeparović, V., Gamulin, M., Šeparović, R. ... Krušlin, B. (2011). Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study. Croatian Medical Journal, 52. (2), 171-177. doi: 10.3325/cmj.2011.52.171

Matković, Božica, et al. "Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study." Croatian Medical Journal, vol. 52, br. 2, 2011, str. 171-177. https://doi.org/10.3325/cmj.2011.52.171

Matković, Božica, Antonio Juretić, Giulio C. Spagnoli, Viktor Šeparović, Marija Gamulin, Robert Šeparović, Nera Šarić, Martina Bašić Koretić, Irena Novosel i Božo Krušlin. "Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study." Croatian Medical Journal 52, br. 2 (2011): 171-177. https://doi.org/10.3325/cmj.2011.52.171

Matković, B., et al. (2011) 'Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study', Croatian Medical Journal, 52(2), str. 171-177. doi: 10.3325/cmj.2011.52.171

Matković B, Juretić A, Spagnoli GC, Šeparović V, Gamulin M, Šeparović R, i sur.. Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study. Croatian Medical Journal [Internet]. 15.04.2011. [pristupljeno 14.05.2024.];52(2):171-177. doi: 10.3325/cmj.2011.52.171

B. Matković, et al., "Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study", Croatian Medical Journal, vol. 52, br. 2, str. 171-177, Travanj 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:222059. [Citirano: 14.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:222059
Podaci o radu
Naslov (engleski)Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study
AutorBožica Matković
AutorAntonio Juretić
AutorGiulio C. Spagnoli
AutorViktor Šeparović
AutorMarija Gamulin
AutorRobert Šeparović
AutorNera Šarić
AutorMartina Bašić-Koretić
AutorIrena Novosel
AutorBožo Krušlin
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: To immunohistochemically evaluate the expression of MAGE-A1, MAGE-A, and NY-ESO-1 cancer/testis (C/T) tumor antigens in medullary breast cancer (MBC) tumor samples and to analyze it in relation to the clinicopathological features. ----- METHODS: This retrospective study included samples from 49 patients: 40 with typical MBC and 9 with atypical MBC. Tumor specimens were obtained from patients operated on in the University Hospital for Tumors and the Sisters of Mercy University Hospital, Zagreb, Croatia, from 1999 to 2005. Standard immunohistochemistry was used on archival paraffin-embedded MBC tissues. ----- RESULTS: MAGE-A1, MAGE-A, and NY-ESO-1 antigens were expressed in 33% (16/49), 33% (16/49), and 22% (11/49) of patients, respectively. No difference between the groups with and without C/T tumor antigen expression in age at diagnosis, tumor size, axillary lymph node metastasis, adjuvant therapy, and HER-2 expression was identified. Significantly more patients died in the MAGE-A-positive group than in the MAGE-A-negative group (P=0.010), whereas a borderline significance was found between MAGE-A1-positive and the MAGE-A1-negative group (P=0.079) and between NY-ESO-1-positive and NY-ESO-1-negative group (P=0.117). Overall survival, as evaluated by the Kaplan-Meier curves, was lower in MAGE-A1- (P=0.031), MAGE-A- (P=0.004), NY-ESO-1-positive groups (P=0.077). ----- CONCLUSION: Expression of C/T antigens may represent a marker of potential prognostic relevance in MBC.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 52, br. 2, str. 171-177
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2011.52.171
URN:NBNurn:nbn:hr:105:222059
Datum objave publikacije2011-04-15
URL dokumentahttp://www.cmj.hr/2011/52/2/21495200.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:13:38