prikaz prve stranice dokumenta 3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia
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Scientific paper - Original scientific paper
3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia
European Journal of Human Genetics, 14 (2006), 4; 478-487. https://doi.org/10.1038/sj.ejhg.5201589
Vitart, Veronique; Biloglav, Zrinka; Hayward, Caroline; Janićijević, Branka; Smolej-Narančić, Nina; Barać, Lovorka; Peričić, Marijana; Martinović-Klarić, Irena; Škarić-Jurić, Tatjana; Barbalić, Maja; Polašek, Ozren; Kolčić, Ivana; Carothers, Andrew; Rudan, Pavao; Hastie, Nick; Wright, Alan; Campbell, Harry; Rudan, Igor More authors...

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Vitart, V., Biloglav, Z., Hayward, C., Janićijević, B., Smolej Narančić, N., Barać, L. ... Rudan, I. (2006). 3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia. European Journal of Human Genetics, 14. (4), 478-487. doi: 10.1038/sj.ejhg.5201589

Vitart, Veronique, et al. "3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia." European Journal of Human Genetics, vol. 14, no. 4, 2006, pp. 478-487. https://doi.org/10.1038/sj.ejhg.5201589

Vitart, Veronique, Zrinka Biloglav, Caroline Hayward, Branka Janićijević, Nina Smolej Narančić, Lovorka Barać, Marijana Peričić, et al. "3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia." European Journal of Human Genetics 14, no. 4 (2006): 478-487. https://doi.org/10.1038/sj.ejhg.5201589

Vitart, V., et al. (2006) '3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia', European Journal of Human Genetics, 14(4), pp. 478-487. doi: 10.1038/sj.ejhg.5201589

Vitart V, Biloglav Z, Hayward C, Janićijević B, Smolej Narančić N, Barać L, and sur.. 3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia. European Journal of Human Genetics [Internet]. 2006 April [cited 2024 April 30];14(4):478-487. doi: 10.1038/sj.ejhg.5201589

V. Vitart, et al., "3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia", European Journal of Human Genetics, vol. 14, no. 4, pp. 478-487, April 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:792918. [Accessed: 30 April 2024]

Metadata
Title (english)3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia
AuthorVeronique Vitart
AuthorZrinka Biloglav
AuthorCaroline Hayward
AuthorBranka Janićijević
AuthorNina Smolej-Narančić
AuthorLovorka Barać
AuthorMarijana Peričić
AuthorIrena Martinović-Klarić
AuthorTatjana Škarić-Jurić
AuthorMaja Barbalić
AuthorOzren Polašek
AuthorIvana Kolčić
AuthorAndrew Carothers
AuthorPavao Rudan
AuthorNick Hastie
AuthorAlan Wright
AuthorHarry Campbell
AuthorIgor Rudan
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Abstract (english)
Communities with increased shared ancestry represent invaluable tools for genetic studies of complex traits. '1001 Dalmatians' research program collects biomedical information for genetic epidemiological research from multiple small isolated populations ('metapopulation') in the islands of Dalmatia, Croatia. Random samples of 100 individuals from 10 small island settlements (n<2000 inhabitants) were collected in 2002 and 2003. These island communities were carefully chosen to represent a wide range of distinct and well-documented demographic histories. Here, we analysed their genetic make-up using 26 short tandem repeat (STR) markers, at least 5 cM apart. We found a very high level of differentiation between most of these island communities based on Wright's fixation indexes, even within the same island. The model-based clustering algorithm, implemented in STRUCTURE, defined six clusters with very distinct genetic signatures, four of which corresponded to single villages. The extent of background LD, assessed with eight linked markers on Xq13-21, paralleled the extent of differentiation and was also very high in most of the populations under study. For each population, demographic history was characterised and 12 'demographic history' variables were tentatively defined. Following stepwise regression, the demographic history variable that most significantly predicted the extent of LD was the proportion of locally born grandparents. Strong isolation and endogamy are likely to be the main forces maintaining this highly structured overall population.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleEuropean Journal of Human Genetics
Numberingvol. 14, no. 4, pp. 478-487
p-ISSN1018-4813
DOIhttps://doi.org/10.1038/sj.ejhg.5201589
URN:NBNurn:nbn:hr:105:792918
Publication2006-04
Document URLhttps://doi.org/10.1038/sj.ejhg.5201589
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:22:12