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3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia
European Journal of Human Genetics, 14 (2006), 4; 478-487. https://doi.org/10.1038/sj.ejhg.5201589
Vitart, Veronique; Biloglav, Zrinka; Hayward, Caroline; Janićijević, Branka; Smolej-Narančić, Nina; Barać, Lovorka; Peričić, Marijana; Martinović-Klarić, Irena; Škarić-Jurić, Tatjana; Barbalić, Maja; Polašek, Ozren; Kolčić, Ivana; Carothers, Andrew; Rudan, Pavao; Hastie, Nick; Wright, Alan; Campbell, Harry; Rudan, Igor Više autora...

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Vitart, V., Biloglav, Z., Hayward, C., Janićijević, B., Smolej Narančić, N., Barać, L. ... Rudan, I. (2006). 3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia. European Journal of Human Genetics, 14. (4), 478-487. doi: 10.1038/sj.ejhg.5201589

Vitart, Veronique, et al. "3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia." European Journal of Human Genetics, vol. 14, br. 4, 2006, str. 478-487. https://doi.org/10.1038/sj.ejhg.5201589

Vitart, Veronique, Zrinka Biloglav, Caroline Hayward, Branka Janićijević, Nina Smolej Narančić, Lovorka Barać, Marijana Peričić, et al. "3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia." European Journal of Human Genetics 14, br. 4 (2006): 478-487. https://doi.org/10.1038/sj.ejhg.5201589

Vitart, V., et al. (2006) '3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia', European Journal of Human Genetics, 14(4), str. 478-487. doi: 10.1038/sj.ejhg.5201589

Vitart V, Biloglav Z, Hayward C, Janićijević B, Smolej Narančić N, Barać L, i sur.. 3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia. European Journal of Human Genetics [Internet]. 04.2006. [pristupljeno 26.11.2024.];14(4):478-487. doi: 10.1038/sj.ejhg.5201589

V. Vitart, et al., "3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia", European Journal of Human Genetics, vol. 14, br. 4, str. 478-487, Travanj 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:792918. [Citirano: 26.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:792918
Podaci o radu
Naslov (engleski)3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia
AutorVeronique Vitart
AutorZrinka Biloglav
AutorCaroline Hayward
AutorBranka Janićijević
AutorNina Smolej-Narančić
AutorLovorka Barać
AutorMarijana Peričić
AutorIrena Martinović-Klarić
AutorTatjana Škarić-Jurić
AutorMaja Barbalić
AutorOzren Polašek
AutorIvana Kolčić
AutorAndrew Carothers
AutorPavao Rudan
AutorNick Hastie
AutorAlan Wright
AutorHarry Campbell
AutorIgor Rudan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Sažetak (engleski)
Communities with increased shared ancestry represent invaluable tools for genetic studies of complex traits. '1001 Dalmatians' research program collects biomedical information for genetic epidemiological research from multiple small isolated populations ('metapopulation') in the islands of Dalmatia, Croatia. Random samples of 100 individuals from 10 small island settlements (n<2000 inhabitants) were collected in 2002 and 2003. These island communities were carefully chosen to represent a wide range of distinct and well-documented demographic histories. Here, we analysed their genetic make-up using 26 short tandem repeat (STR) markers, at least 5 cM apart. We found a very high level of differentiation between most of these island communities based on Wright's fixation indexes, even within the same island. The model-based clustering algorithm, implemented in STRUCTURE, defined six clusters with very distinct genetic signatures, four of which corresponded to single villages. The extent of background LD, assessed with eight linked markers on Xq13-21, paralleled the extent of differentiation and was also very high in most of the populations under study. For each population, demographic history was characterised and 12 'demographic history' variables were tentatively defined. Following stepwise regression, the demographic history variable that most significantly predicted the extent of LD was the proportion of locally born grandparents. Strong isolation and endogamy are likely to be the main forces maintaining this highly structured overall population.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaEuropean Journal of Human Genetics
Brojčani podacivol. 14, br. 4, str. 478-487
p-ISSN1018-4813
DOIhttps://doi.org/10.1038/sj.ejhg.5201589
URN:NBNurn:nbn:hr:105:792918
Datum objave publikacije2006-04
URL dokumentahttps://doi.org/10.1038/sj.ejhg.5201589
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:22:12