prikaz prve stranice dokumenta The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents
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Scientific paper - Original scientific paper
The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents
Psychopharmacology, 220 (2012), 3; 639-641. https://doi.org/10.1007/s00213-011-2607-7
Podobnik, Josip; Foller Podobnik, Iris; Grgić, Neda; Marčinko, Darko; Pivac, Nela

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Podobnik, J., Foller Podobnik, I., Grgić, N., Marčinko, D. & Pivac, N. (2012). The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents. Psychopharmacology, 220. (3), 639-641. doi: 10.1007/s00213-011-2607-7

Podobnik, Josip, et al. "The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents." Psychopharmacology, vol. 220, no. 3, 2012, pp. 639-641. https://doi.org/10.1007/s00213-011-2607-7

Podobnik, Josip, Iris Foller Podobnik, Neda Grgić, Darko Marčinko and Nela Pivac. "The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents." Psychopharmacology 220, no. 3 (2012): 639-641. https://doi.org/10.1007/s00213-011-2607-7

Podobnik, J., et al. (2012) 'The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents', Psychopharmacology, 220(3), pp. 639-641. doi: 10.1007/s00213-011-2607-7

Podobnik J, Foller Podobnik I, Grgić N, Marčinko D, Pivac N. The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents. Psychopharmacology [Internet]. 2012 April [cited 2024 May 07];220(3):639-641. doi: 10.1007/s00213-011-2607-7

J. Podobnik, I. Foller Podobnik, N. Grgić, D. Marčinko and N. Pivac, "The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents", Psychopharmacology, vol. 220, no. 3, pp. 639-641, April 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:786828. [Accessed: 07 May 2024]

Metadata
Title (english)The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents
AuthorJosip Podobnik
AuthorIris Foller Podobnik
AuthorNeda Grgić
AuthorDarko Marčinko
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Rationale Atypical antipsychotics are frequently prescribed for psychotic and mood disorders in youth, and for symptoms of depression, aggression, irritability and suicidal tendencies, which are associated with subsequent development of borderline personality disorders (BPD). ----- Objectives This study evaluated the effects of 24-weeks of add-on treatment with quetiapine to selective serotonin reuptake inhibitors (SSRIs) in young people with pronounced symptoms of depression, aggression, irritability and suicidal tendencies. ----- Methods In an open-label 24-weeks trial, 22 SSRI-treatment resistant patients (age range 9-18 years) with developing BPD were treated with quetiapine (75-600 mg/day) in combination with SSRIs. Symptoms of depression, aggression, irritability and suicidal tendencies were rated with the Overt Aggression Scale Modified (OAS-M), Kutcher Adolescent Depression Scale (KADS-6) and Children Global Assessment Scale (C-GAS) before and after 4-24 weeks of treatment. ----- Results Quetiapine induced significant (p<0.001) improvement after 4-24 weeks, with a modest but significant increase in the C-GAS total scores (i.e. children’s general clinical status), and a significant reduction of the total scores in OAS-M, KADS-6 and OAS-M subscales for aggression, irritability and suicidality. There were no discontinuations for adverse effects. Conclusions These preliminary results suggest that quetiapine addition to SSRIs treatment significantly reduced symptoms of depression, aggression, irritability and suicidal tendencies in young people with developing BPD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePsychopharmacology
Numberingvol. 220, no. 3, pp. 639-641
p-ISSN0033-3158
DOIhttps://doi.org/10.1007/s00213-011-2607-7
URN:NBNurn:nbn:hr:105:786828
Publication2012-04
Document URLhttps://doi.org/10.1007/s00213-011-2607-7
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:27:15