prikaz prve stranice dokumenta The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents
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The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents
Psychopharmacology, 220 (2012), 3; 639-641. https://doi.org/10.1007/s00213-011-2607-7
Podobnik, Josip; Foller Podobnik, Iris; Grgić, Neda; Marčinko, Darko; Pivac, Nela

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Podobnik, J., Foller Podobnik, I., Grgić, N., Marčinko, D. i Pivac, N. (2012). The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents. Psychopharmacology, 220. (3), 639-641. doi: 10.1007/s00213-011-2607-7

Podobnik, Josip, et al. "The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents." Psychopharmacology, vol. 220, br. 3, 2012, str. 639-641. https://doi.org/10.1007/s00213-011-2607-7

Podobnik, Josip, Iris Foller Podobnik, Neda Grgić, Darko Marčinko i Nela Pivac. "The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents." Psychopharmacology 220, br. 3 (2012): 639-641. https://doi.org/10.1007/s00213-011-2607-7

Podobnik, J., et al. (2012) 'The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents', Psychopharmacology, 220(3), str. 639-641. doi: 10.1007/s00213-011-2607-7

Podobnik J, Foller Podobnik I, Grgić N, Marčinko D, Pivac N. The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents. Psychopharmacology [Internet]. 04.2012. [pristupljeno 29.11.2024.];220(3):639-641. doi: 10.1007/s00213-011-2607-7

J. Podobnik, I. Foller Podobnik, N. Grgić, D. Marčinko i N. Pivac, "The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents", Psychopharmacology, vol. 220, br. 3, str. 639-641, Travanj 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:786828. [Citirano: 29.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:786828
Podaci o radu
Naslov (engleski)The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents
AutorJosip Podobnik
AutorIris Foller Podobnik
AutorNeda Grgić
AutorDarko Marčinko
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Rationale Atypical antipsychotics are frequently prescribed for psychotic and mood disorders in youth, and for symptoms of depression, aggression, irritability and suicidal tendencies, which are associated with subsequent development of borderline personality disorders (BPD). ----- Objectives This study evaluated the effects of 24-weeks of add-on treatment with quetiapine to selective serotonin reuptake inhibitors (SSRIs) in young people with pronounced symptoms of depression, aggression, irritability and suicidal tendencies. ----- Methods In an open-label 24-weeks trial, 22 SSRI-treatment resistant patients (age range 9-18 years) with developing BPD were treated with quetiapine (75-600 mg/day) in combination with SSRIs. Symptoms of depression, aggression, irritability and suicidal tendencies were rated with the Overt Aggression Scale Modified (OAS-M), Kutcher Adolescent Depression Scale (KADS-6) and Children Global Assessment Scale (C-GAS) before and after 4-24 weeks of treatment. ----- Results Quetiapine induced significant (p<0.001) improvement after 4-24 weeks, with a modest but significant increase in the C-GAS total scores (i.e. children’s general clinical status), and a significant reduction of the total scores in OAS-M, KADS-6 and OAS-M subscales for aggression, irritability and suicidality. There were no discontinuations for adverse effects. Conclusions These preliminary results suggest that quetiapine addition to SSRIs treatment significantly reduced symptoms of depression, aggression, irritability and suicidal tendencies in young people with developing BPD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaPsychopharmacology
Brojčani podacivol. 220, br. 3, str. 639-641
p-ISSN0033-3158
DOIhttps://doi.org/10.1007/s00213-011-2607-7
URN:NBNurn:nbn:hr:105:786828
Datum objave publikacije2012-04
URL dokumentahttps://doi.org/10.1007/s00213-011-2607-7
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:27:15