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Scientific paper - Original scientific paper
Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants
Journal of Psychiatric Research, 46 (2012), 6; 767-773. https://doi.org/10.1016/j.jpsychires.2012.03.008
Božina, Nada; Jovanović, Nikolina; Podlesek, Anja; Rojnić Kuzman, Martina; Kudumija Slijepčević, Marija; Roguljić, Ana; Dimitrović, Ana; Božina, Tamara; Lovrić, Jasna; Ljubić, Hana; Medved, Vesna

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Božina, N., Jovanović, N., Podlesek, A., Rojnić Kuzman, M., Kudumija Slijepčević, M., Roguljić, A. ... Medved, V. (2012). Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants. Journal of Psychiatric Research, 46. (6), 767-773. doi: 10.1016/j.jpsychires.2012.03.008

Božina, Nada, et al. "Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants." Journal of Psychiatric Research, vol. 46, no. 6, 2012, pp. 767-773. https://doi.org/10.1016/j.jpsychires.2012.03.008

Božina, Nada, Nikolina Jovanović, Anja Podlesek, Martina Rojnić Kuzman, Marija Kudumija Slijepčević, Ana Roguljić, Ana Dimitrović, et al. "Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants." Journal of Psychiatric Research 46, no. 6 (2012): 767-773. https://doi.org/10.1016/j.jpsychires.2012.03.008

Božina, N., et al. (2012) 'Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants', Journal of Psychiatric Research, 46(6), pp. 767-773. doi: 10.1016/j.jpsychires.2012.03.008

Božina N, Jovanović N, Podlesek A, Rojnić Kuzman M, Kudumija Slijepčević M, Roguljić A, and sur.. Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants. Journal of Psychiatric Research [Internet]. 2012 June [cited 2024 April 27];46(6):767-773. doi: 10.1016/j.jpsychires.2012.03.008

N. Božina, et al., "Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants", Journal of Psychiatric Research, vol. 46, no. 6, pp. 767-773, June 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:628270. [Accessed: 27 April 2024]

Metadata
Title (english)Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants
AuthorNada Božina
AuthorNikolina Jovanović
AuthorAnja Podlesek
AuthorMartina Rojnić Kuzman
AuthorMarija Kudumija Slijepčević
AuthorAna Roguljić
AuthorAna Dimitrović
AuthorTamara Božina
AuthorJasna Lovrić
AuthorHana Ljubić
AuthorVesna Medved
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To examine the role of 5-HTTLPR, rs25531 and 5-HTT VNTR Intron 2 variants in subjects with psychotic disorders manifesting suicide ideation and behaviour. ----- METHODS: The study included 519 subsequently hospitalized subjects who were genotyped for 5-HTTLPR, rs25531 and 5-HTT VNTR In2 variants. Clinical assessments included structured psychiatric interview, sociodemographic characteristics, suicide ideation and behaviour (SIBQ), severity of psychopathology (PANSS) and depression (CDSS). ----- RESULTS: Three subgroups were identified: suicide attempters (N = 161), suicide ideators (N = 174) and subjects who never reported suicide ideation or behaviour (comparative group, N = 184). Major findings: 1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution. ----- CONCLUSION: The suicide ideators, attempters and controls did not differ significantly in 5-HTTLPR or 5-HTT VNTR In 2 variants, but 5-HTTLPR/5-HTT rs25531 haplotype might be a useful genetic marker in distinguishing these three clinical groups.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Psychiatric Research
Numberingvol. 46, no. 6, pp. 767-773
p-ISSN0022-3956
DOIhttps://doi.org/10.1016/j.jpsychires.2012.03.008
URN:NBNurn:nbn:hr:105:628270
Publication2012-06
Document URLhttps://doi.org/10.1016/j.jpsychires.2012.03.008
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:30:37