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Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants
Journal of Psychiatric Research, 46 (2012), 6; 767-773. https://doi.org/10.1016/j.jpsychires.2012.03.008
Božina, Nada; Jovanović, Nikolina; Podlesek, Anja; Rojnić Kuzman, Martina; Kudumija Slijepčević, Marija; Roguljić, Ana; Dimitrović, Ana; Božina, Tamara; Lovrić, Jasna; Ljubić, Hana; Medved, Vesna

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Božina, N., Jovanović, N., Podlesek, A., Rojnić Kuzman, M., Kudumija Slijepčević, M., Roguljić, A. ... Medved, V. (2012). Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants. Journal of Psychiatric Research, 46. (6), 767-773. doi: 10.1016/j.jpsychires.2012.03.008

Božina, Nada, et al. "Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants." Journal of Psychiatric Research, vol. 46, br. 6, 2012, str. 767-773. https://doi.org/10.1016/j.jpsychires.2012.03.008

Božina, Nada, Nikolina Jovanović, Anja Podlesek, Martina Rojnić Kuzman, Marija Kudumija Slijepčević, Ana Roguljić, Ana Dimitrović, et al. "Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants." Journal of Psychiatric Research 46, br. 6 (2012): 767-773. https://doi.org/10.1016/j.jpsychires.2012.03.008

Božina, N., et al. (2012) 'Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants', Journal of Psychiatric Research, 46(6), str. 767-773. doi: 10.1016/j.jpsychires.2012.03.008

Božina N, Jovanović N, Podlesek A, Rojnić Kuzman M, Kudumija Slijepčević M, Roguljić A, i sur.. Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants. Journal of Psychiatric Research [Internet]. 06.2012. [pristupljeno 31.01.2025.];46(6):767-773. doi: 10.1016/j.jpsychires.2012.03.008

N. Božina, et al., "Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants", Journal of Psychiatric Research, vol. 46, br. 6, str. 767-773, Lipanj 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:628270. [Citirano: 31.01.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:628270
Podaci o radu
Naslov (engleski)Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants
AutorNada Božina
AutorNikolina Jovanović
AutorAnja Podlesek
AutorMartina Rojnić Kuzman
AutorMarija Kudumija Slijepčević
AutorAna Roguljić
AutorAna Dimitrović
AutorTamara Božina
AutorJasna Lovrić
AutorHana Ljubić
AutorVesna Medved
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: To examine the role of 5-HTTLPR, rs25531 and 5-HTT VNTR Intron 2 variants in subjects with psychotic disorders manifesting suicide ideation and behaviour. ----- METHODS: The study included 519 subsequently hospitalized subjects who were genotyped for 5-HTTLPR, rs25531 and 5-HTT VNTR In2 variants. Clinical assessments included structured psychiatric interview, sociodemographic characteristics, suicide ideation and behaviour (SIBQ), severity of psychopathology (PANSS) and depression (CDSS). ----- RESULTS: Three subgroups were identified: suicide attempters (N = 161), suicide ideators (N = 174) and subjects who never reported suicide ideation or behaviour (comparative group, N = 184). Major findings: 1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution. ----- CONCLUSION: The suicide ideators, attempters and controls did not differ significantly in 5-HTTLPR or 5-HTT VNTR In 2 variants, but 5-HTTLPR/5-HTT rs25531 haplotype might be a useful genetic marker in distinguishing these three clinical groups.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Psychiatric Research
Brojčani podacivol. 46, br. 6, str. 767-773
p-ISSN0022-3956
DOIhttps://doi.org/10.1016/j.jpsychires.2012.03.008
URN:NBNurn:nbn:hr:105:628270
Datum objave publikacije2012-06
URL dokumentahttps://doi.org/10.1016/j.jpsychires.2012.03.008
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:30:37