prikaz prve stranice dokumenta Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study
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Scientific paper - Original scientific paper
Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study
Rheumatology International, 32 (2012), 9; 2801-2808. https://doi.org/10.1007/s00296-011-2066-9
Grazio, Simeon; Kusić, Zvonko; Cvijetić, Selma; Grubišić, Frane; Balenović, Antonija; Nemčić, Tomislav; Matijević-Mikelić, Valentina; Punda, Marija; Sieper, Joachim

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Grazio, S., Kusić, Z., Cvijetić, S., Grubišić, F., Balenović, A., Nemčić, T. ... Sieper, J. (2012). Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study. Rheumatology International, 32. (9), 2801-2808. doi: 10.1007/s00296-011-2066-9

Grazio, Simeon, et al. "Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study." Rheumatology International, vol. 32, no. 9, 2012, pp. 2801-2808. https://doi.org/10.1007/s00296-011-2066-9

Grazio, Simeon, Zvonko Kusić, Selma Cvijetić, Frane Grubišić, Antonija Balenović, Tomislav Nemčić, Valentina Matijević Mikelić, Marija Punda and Joachim Sieper. "Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study." Rheumatology International 32, no. 9 (2012): 2801-2808. https://doi.org/10.1007/s00296-011-2066-9

Grazio, S., et al. (2012) 'Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study', Rheumatology International, 32(9), pp. 2801-2808. doi: 10.1007/s00296-011-2066-9

Grazio S, Kusić Z, Cvijetić S, Grubišić F, Balenović A, Nemčić T, and sur.. Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study. Rheumatology International [Internet]. 2012 September [cited 2024 November 26];32(9):2801-2808. doi: 10.1007/s00296-011-2066-9

S. Grazio, et al., "Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study", Rheumatology International, vol. 32, no. 9, pp. 2801-2808, September 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:714535. [Accessed: 26 November 2024]

Metadata
Title (english)Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study
AuthorSimeon Grazio
AuthorZvonko Kusić
AuthorSelma Cvijetić
AuthorFrane Grubišić
AuthorAntonija Balenović
AuthorTomislav Nemčić
AuthorValentina Matijević-Mikelić
AuthorMarija Punda
AuthorJoachim Sieper
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
In ankylosing spondylitis, inflammatory activity probably plays a key role in the pathophysiology of bone loss. The aim of the study was to investigate the relationship of bone mineral density (BMD) at the lumbar spine and hip region with some measures of disease activity and functional ability in patients with ankylosing spondylitis. In 80 patients with established ankylosing spondylitis, disease activity and functional ability were determined by C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). Spinal pain and patient global health were assessed using horizontal visual analog scale. BMD was measured by dual-energy X-ray absorptiometry. There was a significant negative correlation of bone density T scores with acute-phase reactants (i.e., patients with lower T scores had higher level of CRP and ESR). That relationship was reflected more reliably at proximal femur sites than at the lumbar spine. There were also significant differences in ESR, BASDAI, BASFI, spinal pain and global health between three groups of patients according to WHO classification of osteoporosis (normal, osteopenic and osteoporotic). Significantly, more patients with osteopenia at the lumbar spine had lower BASDAI index than those with normal BMD (P = 0.030). Our results indicate an association of low BMD with high disease activity in patients with AS. Femoral BMD seems to be more associated with disease activity and functional ability than lumbar spine BMD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleRheumatology International
Numberingvol. 32, no. 9, pp. 2801-2808
p-ISSN0172-8172
DOIhttps://doi.org/10.1007/s00296-011-2066-9
URN:NBNurn:nbn:hr:105:714535
Publication2012-09
Document URLhttps://doi.org/10.1007/s00296-011-2066-9
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:31:24