prikaz prve stranice dokumenta Increased expression of endothelial lipase in symptomatic and unstable carotid plaques
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Scientific paper - Original scientific paper
Increased expression of endothelial lipase in symptomatic and unstable carotid plaques
Journal of Neurology, 259 (2012), 3; 448-456. https://doi.org/10.1007/s00415-011-6198-3
Trbušić, Matias; Riederer, Monika; Vučić, Majda; Lovričević, Ivo; Krušlin, Božo; Gauster, Martin; Mohrenz, Sonja; Berghold, Andrea; Tiran, Beate; Degoricija, Vesna; Frank, Saša

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Trbušić, M., Riederer, M., Vučić, M., Lovričević, I., Krušlin, B., Gauster, M. ... Frank, S. (2012). Increased expression of endothelial lipase in symptomatic and unstable carotid plaques. Journal of Neurology, 259. (3), 448-456. doi: 10.1007/s00415-011-6198-3

Trbušić, Matias, et al. "Increased expression of endothelial lipase in symptomatic and unstable carotid plaques." Journal of Neurology, vol. 259, no. 3, 2012, pp. 448-456. https://doi.org/10.1007/s00415-011-6198-3

Trbušić, Matias, Monika Riederer, Majda Vučić, Ivo Lovričević, Božo Krušlin, Martin Gauster, Sonja Mohrenz, et al. "Increased expression of endothelial lipase in symptomatic and unstable carotid plaques." Journal of Neurology 259, no. 3 (2012): 448-456. https://doi.org/10.1007/s00415-011-6198-3

Trbušić, M., et al. (2012) 'Increased expression of endothelial lipase in symptomatic and unstable carotid plaques', Journal of Neurology, 259(3), pp. 448-456. doi: 10.1007/s00415-011-6198-3

Trbušić M, Riederer M, Vučić M, Lovričević I, Krušlin B, Gauster M, and sur.. Increased expression of endothelial lipase in symptomatic and unstable carotid plaques. Journal of Neurology [Internet]. 2012 March [cited 2024 November 26];259(3):448-456. doi: 10.1007/s00415-011-6198-3

M. Trbušić, et al., "Increased expression of endothelial lipase in symptomatic and unstable carotid plaques", Journal of Neurology, vol. 259, no. 3, pp. 448-456, March 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:659357. [Accessed: 26 November 2024]

Metadata
Title (english)Increased expression of endothelial lipase in symptomatic and unstable carotid plaques
AuthorMatias Trbušić
AuthorMonika Riederer
AuthorMajda Vučić
AuthorIvo Lovričević
AuthorBožo Krušlin
AuthorMartin Gauster
AuthorSonja Mohrenz
AuthorAndrea Berghold
AuthorBeate Tiran
AuthorVesna Degoricija
AuthorSaša Frank
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of this study was to evaluate endothelial lipase (EL) protein expression in advanced human carotid artery plaques (HCAP) with regard to plaque (in)stability and the incidence of symptoms. HCAP were collected from 66 patients undergoing carotid endarterectomy (CEA). The degree of plaque (in)stability was estimated by ultrasound and histology. In HCAP sections, EL expression was determined by immunostaining and the intensity was assessed on a semi-quantitative scale (low: <25%, high: >25% positive cells). Monocytes and macrophages in adjacent HCAP sections were stained with a CD163 specific antibody. High EL staining was more prevalent in histologically unstable plaques (in 33.3% of fibrous plaques, 50% of ulcerated non-complicated plaques and 79.2% of ulcerated complicated plaques; χ(2) test, p = 0.004) and in the symptomatic group (70.8 vs. 42.9% in the asymptomatic group; χ(2) test, p = 0.028). The majority of EL immunostaining was found in those HCAP regions exhibiting a strong CD163 immunostaining. EL in HCAP might be a marker and/or promoter of plaque instability and HCAP-related symptomatology.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Neurology
Numberingvol. 259, no. 3, pp. 448-456
p-ISSN0340-5354
DOIhttps://doi.org/10.1007/s00415-011-6198-3
URN:NBNurn:nbn:hr:105:659357
Publication2012-03
Document URLhttps://doi.org/10.1007/s00415-011-6198-3
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:32:51