prikaz prve stranice dokumenta Increased expression of endothelial lipase in symptomatic and unstable carotid plaques
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Increased expression of endothelial lipase in symptomatic and unstable carotid plaques
Journal of Neurology, 259 (2012), 3; 448-456. https://doi.org/10.1007/s00415-011-6198-3
Trbušić, Matias; Riederer, Monika; Vučić, Majda; Lovričević, Ivo; Krušlin, Božo; Gauster, Martin; Mohrenz, Sonja; Berghold, Andrea; Tiran, Beate; Degoricija, Vesna; Frank, Saša

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Trbušić, M., Riederer, M., Vučić, M., Lovričević, I., Krušlin, B., Gauster, M. ... Frank, S. (2012). Increased expression of endothelial lipase in symptomatic and unstable carotid plaques. Journal of Neurology, 259. (3), 448-456. doi: 10.1007/s00415-011-6198-3

Trbušić, Matias, et al. "Increased expression of endothelial lipase in symptomatic and unstable carotid plaques." Journal of Neurology, vol. 259, br. 3, 2012, str. 448-456. https://doi.org/10.1007/s00415-011-6198-3

Trbušić, Matias, Monika Riederer, Majda Vučić, Ivo Lovričević, Božo Krušlin, Martin Gauster, Sonja Mohrenz, et al. "Increased expression of endothelial lipase in symptomatic and unstable carotid plaques." Journal of Neurology 259, br. 3 (2012): 448-456. https://doi.org/10.1007/s00415-011-6198-3

Trbušić, M., et al. (2012) 'Increased expression of endothelial lipase in symptomatic and unstable carotid plaques', Journal of Neurology, 259(3), str. 448-456. doi: 10.1007/s00415-011-6198-3

Trbušić M, Riederer M, Vučić M, Lovričević I, Krušlin B, Gauster M, i sur.. Increased expression of endothelial lipase in symptomatic and unstable carotid plaques. Journal of Neurology [Internet]. 03.2012. [pristupljeno 22.11.2024.];259(3):448-456. doi: 10.1007/s00415-011-6198-3

M. Trbušić, et al., "Increased expression of endothelial lipase in symptomatic and unstable carotid plaques", Journal of Neurology, vol. 259, br. 3, str. 448-456, Ožujak 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:659357. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:659357
Podaci o radu
Naslov (engleski)Increased expression of endothelial lipase in symptomatic and unstable carotid plaques
AutorMatias Trbušić
AutorMonika Riederer
AutorMajda Vučić
AutorIvo Lovričević
AutorBožo Krušlin
AutorMartin Gauster
AutorSonja Mohrenz
AutorAndrea Berghold
AutorBeate Tiran
AutorVesna Degoricija
AutorSaša Frank
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The aim of this study was to evaluate endothelial lipase (EL) protein expression in advanced human carotid artery plaques (HCAP) with regard to plaque (in)stability and the incidence of symptoms. HCAP were collected from 66 patients undergoing carotid endarterectomy (CEA). The degree of plaque (in)stability was estimated by ultrasound and histology. In HCAP sections, EL expression was determined by immunostaining and the intensity was assessed on a semi-quantitative scale (low: <25%, high: >25% positive cells). Monocytes and macrophages in adjacent HCAP sections were stained with a CD163 specific antibody. High EL staining was more prevalent in histologically unstable plaques (in 33.3% of fibrous plaques, 50% of ulcerated non-complicated plaques and 79.2% of ulcerated complicated plaques; χ(2) test, p = 0.004) and in the symptomatic group (70.8 vs. 42.9% in the asymptomatic group; χ(2) test, p = 0.028). The majority of EL immunostaining was found in those HCAP regions exhibiting a strong CD163 immunostaining. EL in HCAP might be a marker and/or promoter of plaque instability and HCAP-related symptomatology.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Neurology
Brojčani podacivol. 259, br. 3, str. 448-456
p-ISSN0340-5354
DOIhttps://doi.org/10.1007/s00415-011-6198-3
URN:NBNurn:nbn:hr:105:659357
Datum objave publikacije2012-03
URL dokumentahttps://doi.org/10.1007/s00415-011-6198-3
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:32:51